Literature DB >> 7925849

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets.

M H Antoine1, B Pirotte, M Hermann, P de Tullio, J Delarge, A Herchuelz, P Lebrun.   

Abstract

The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothiadiazine derivative, and diazoxide on 86Rb outflow, 45Ca outflow, 45Ca uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the KATP channels.

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Year:  1994        PMID： 7925849     DOI： 10.1007/bf01956464

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

Review 1.  K+ channel openers and insulin release.

Authors:  P Lebrun; M H Antoine; A Herchuelz
Journal:  Life Sci       Date:  1992       Impact factor: 5.037

2.  3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

Authors:  B Pirotte; P de Tullio; P Lebrun; M H Antoine; J Fontaine; B Masereel; M Schynts; L Dupont; A Herchuelz; J Delarge
Journal:  J Med Chem       Date:  1993-10-15       Impact factor: 7.446

3.  Similarities between the effects of pinacidil and diazoxide on ionic and secretory events in rat pancreatic islets.

Authors:  P Lebrun; V Devreux; M Hermann; A Herchuelz
Journal:  J Pharmacol Exp Ther       Date:  1989-09       Impact factor: 4.030

4.  A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels.

Authors:  B Pirotte; M H Antoine; P de Tullio; M Hermann; A Herchuelz; J Delarge; P Lebrun
Journal:  Biochem Pharmacol       Date:  1994-04-20       Impact factor: 5.858

5.  Sodium nitroprusside inhibits glucose-induced insulin release by activating ATP-sensitive K+ channels.

Authors:  M H Antoine; M Hermann; A Herchuelz; P Lebrun
Journal:  Biochim Biophys Acta       Date:  1993-02-17

6.  Regulation of calcium fluxes in pancreatic islets: glucose-induced calcium-calcium exchange.

Authors:  A Herchuelz; E Couturier; W J Malaisse
Journal:  Am J Physiol       Date:  1980-02
  6 in total

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