Impact of the menopause on the epidemiology and risk factors of coronary artery heart disease in women.

Cardiovascular disease is the leading cause of morbidity and mortality in women, and coronary artery heart disease (CHD) is the largest single component of fatal cardiovascular disease. Gender-related differences are observed in the symptomatology, natural course and outcome, and in the management of the acute coronary event. More women, compared to men, have angina as their first manifestation of CHD, and they are less likely to have serious stenosis. Women undergo less invasive diagnostic procedures, but have an overall prognosis that is worse than that of men. Rates of CHD in women increase after the fifth-sixth decades of life, suggesting that young women have a protective factor that is lost after the fifth decade. Because most women become menopausal during this age range, it is speculated that the protective factor may the female hormone, estrogen. This conclusion is supported by results of epidemiological studies indicating an increased risk of CHD in women with early-onset menopause and a reduced risk in postmenopausal women treated with estrogen replacement therapy. The impact of the menopausal transition on other CHD risk factors is still not fully understood. Reduced estrogen levels resulting from the menopausal transition have been implicated in adverse effects on obesity and fat distribution, plasma lipid profile, and rheological properties of plasma and platelet function. Postmenopausal estrogen deficiency may also aggravate preexisting diabetes mellitus and hypertension, and have an overall negative effect on the reaction to stress. These data suggest that estrogen deficiency can directly and indirectly promote CHD in women. More research is needed to clarify and differentiate menopause-related from aging-related effects on the risk of CHD women.