Literature DB >> 7925595

Differential effects of omega-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat vas deferens.

J R Boot1.   

Abstract

omega-Conotoxin GVIA and omega-conotoxin MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The inhibitory effects of omega-conotoxin GVIA were long-lasting whereas those to omega-conotoxin MVIIC were readily reversed. Preincubation with omega-conotoxin MVIIC prevented the irreversible inhibition of omega-conotoxin GVIA suggesting a common site of interaction. However, unlike omega-conotoxin GVIA which caused inhibition, omega-conotoxin MVIIC did not affect the electrically induced twitch responses of the rat vas deferens nor did it prevent the irreversible inhibition with omega-conotoxin GVIA. This study indicates the possible existence of different subtypes of the N-type voltage-dependent calcium channel.

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Year:  1994        PMID： 7925595     DOI： 10.1016/0014-2999(94)90069-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Calcium channel subtypes for cholinergic and nonadrenergic noncholinergic neurotransmission in isolated guinea pig trachea.

Authors:  Chung-Hung Shih; Hsin-Te Hsu; Kuo-Hsien Wang; Chih-Hsieh Shih; Wun-Chang Ko
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-09-05       Impact factor: 3.000

2.  Multiple subtypes of voltage-gated calcium channel mediate transmitter release from parasympathetic neurons in the mouse bladder.

Authors:  S A Waterman
Journal:  J Neurosci       Date:  1996-07-01       Impact factor: 6.167

3.  Multiple calcium channels control neurotransmitter release from rat postganglionic sympathetic nerve terminals.

Authors:  A B Smith; T C Cunnane
Journal:  J Physiol       Date:  1997-03-01       Impact factor: 5.182

4.  Upregulation of L-type calcium channels in colonic inhibitory motoneurons of P/Q-type calcium channel-deficient mice.

Authors:  Eileen Rodriguez-Tapia; Alberto Perez-Medina; Xiaochun Bian; James J Galligan
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2016-09-01       Impact factor: 4.052

5.  Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission.

Authors:  C E Wright; J A Angus
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

6.  Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB.

Authors:  S J Hong; Y F Roan; C C Chang
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

7.  Role of N-type calcium channels in autonomic neurotransmission in guinea-pig isolated left atria.

Authors:  A P Serone; J A Angus
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

8.  Lack of effect of Z-butylidenephthalide on presynaptic N-type Ca²⁺ channels in isolated guinea-pig ileum.

Authors:  Marcelo Chen; Wun-Chang Ko
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-02       Impact factor: 3.000

9.  Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria.

Authors:  S J Hong; C C Chang
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

10.  Mechanisms of butylidenephthalide for twitch facilitation in electrically stimulated mouse vas deferens.

Authors:  Chung-Hung Shih; Chi-Ming Chen; Wun-Chang Ko
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503
  10 in total

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