Literature DB >> 7924740

Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat.

P S Olsen1, P Kirkegaard, S S Poulsen, E Nexø.   

Abstract

The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmol/kg/hr of secretin. Somatostatin inhibited Brunner's gland secretion, but the total output of EGF remained unchanged. Secretin-stimulated volume secretion and secretion of EGF was significantly reduced by simultaneous infusion of somatostatin. This study has shown that secretin stimulates secretion of EGF as well as volume secretion from Brunner's glands. Somatostatin prevents the effect of secretin on Brunner's glands, which suggests a role for somatostatin in control of Brunner's gland secretion.

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Year:  1994        PMID： 7924740     DOI： 10.1007/bf02090369

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  23 in total

Review 1.  Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status.

Authors:  M D Hollenberg
Journal:  Vitam Horm       Date:  1979       Impact factor: 3.421

Review 2.  Endogenous somatostatin and the gut.

Authors:  M R Lucey
Journal:  Gut       Date:  1986-04       Impact factor: 23.059

Review 3.  Neural and hormonal control of Brunner's gland secretion.

Authors:  I M Lang; M F Tansy
Journal:  Life Sci       Date:  1982-02-01       Impact factor: 5.037

4.  Plasma secretin concentration and pancreatic exocrine secretion after intravenous secretin or intraduodenal HC1 in anaesthetized pigs.

Authors:  O B Schaffalitzky de Muckadell; J Fahrenkrug; J J Holst
Journal:  Scand J Gastroenterol       Date:  1977       Impact factor: 2.423

5.  Effect of long acting somatostatin-analogue, SMS 201 995, on gut hormone secretion in normal subjects.

Authors:  M E Kraenzlin; S M Wood; M Neufeld; T E Adrian; S R Bloom
Journal:  Experientia       Date:  1985-06-15

6.  Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands.

Authors:  P Kirkegaard; P S Olsen; E Nexø; J J Holst; S S Poulsen
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

7.  Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor.

Authors:  P S Olsen; P Kirkegaard; S S Poulsen; E Nexø
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

8.  Response of circulating somatostatin, insulin, gastrin and GIP, to intraduodenal infusion of nutrients in normal man.

Authors:  M R Lucey; P D Fairclough; J A Wass; P Kwasowski; S Medbak; J Webb; L H Rees
Journal:  Clin Endocrinol (Oxf)       Date:  1984-09       Impact factor: 3.478

9.  Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine.

Authors:  P Kirkegaard; P S Olsen; S S Poulsen; E Nexø
Journal:  Regul Pept       Date:  1983-12

10.  Epidermal growth factor in blood.

Authors:  A P Savage; V K Chatterjee; H Gregory; S R Bloom
Journal:  Regul Pept       Date:  1986-12-30
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  3 in total

Review 1.  Secretin: Should we revisit its metabolic outcomes?

Authors:  D H St-Pierre; F Broglio
Journal:  J Endocrinol Invest       Date:  2010-05-05       Impact factor: 4.256

2.  Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.

Authors:  Laura-I Cosen-Binker; Gerry P Morris; Stephen Vanner; Herbert Y Gaisano
Journal:  World J Gastroenterol       Date:  2008-04-21       Impact factor: 5.742

Review 3.  Secretin as a neuropeptide.

Authors:  Samuel S M Ng; W H Yung; Billy K C Chow
Journal:  Mol Neurobiol       Date:  2002-08       Impact factor: 5.590
  3 in total

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