Literature DB >> 792398

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.

C D Frith, E C Johnston, M H Joseph, R J Powell, R W Watts.   

Abstract

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 792398      PMCID： PMC492397          DOI： 10.1136/jnnp.39.7.656

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  19 in total

1.  Behaviour control of self-biting in a Lesch-Nyhan patient.

Authors:  P Duker
Journal:  J Ment Defic Res       Date:  1975-03

2.  Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration.

Authors:  J W Kebabian; F E Blood; A L Steiner; P Greengard
Journal:  Science       Date:  1975-10-10       Impact factor: 47.728

3.  Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties.

Authors:  I H Fox; W N Kelley
Journal:  J Biol Chem       Date:  1971-09-25       Impact factor: 5.157

4.  Clinical and biochemical studies on treatment of Lesch-Nyhan syndrome.

Authors:  R W Watts; R O McKeran; E Brown; T M Andrews; M I Griffiths
Journal:  Arch Dis Child       Date:  1974-09       Impact factor: 3.791

5.  Hypoxanthine-guanine-phosphoribosyl-transferase from rat brain (purification, kinetic properties, development and distribution).

Authors:  W Gutensohn; G Guroff
Journal:  J Neurochem       Date:  1972-09       Impact factor: 5.372

6.  Studies on human erythrocyte IMP: pyrophosphate phosphoribosyltransferase.

Authors:  J A Craft; B M Dean; R W Watts; W J Westwick
Journal:  Eur J Biochem       Date:  1970-08

7.  Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes.

Authors:  J W Hadden; E M Hadden; M K Haddox; N D Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-10       Impact factor: 11.205

8.  Lesch-Nyhan syndrome: evidence for abnormal adrenergic function.

Authors:  S Rockson; R Stone; M Van der Weyden; W N Kelley
Journal:  Science       Date:  1974-12-06       Impact factor: 47.728

9.  Guanosine 3',5'-monophosphate in sympathetic ganglia: increase assoicated with synaptic transmission.

Authors:  F F Weight; G Petzold; P Greengard
Journal:  Science       Date:  1974-12-06       Impact factor: 47.728

10.  Hypoxanthine-guanine phosphoribosyltransferase: characteristics of the mutant enzyme in erythrocytes from patients with the Lesch-Nyhan syndrome.

Authors:  W J Arnold; J C Meade; W N Kelley
Journal:  J Clin Invest       Date:  1972-07       Impact factor: 14.808
View more
  5 in total

Review 1.  Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.

Authors:  J E Seegmiller
Journal:  Ann Rheum Dis       Date:  1980-04       Impact factor: 19.103

2.  Contributions of Lesch-Nyhan syndrome to the understanding of purine metabolism.

Authors:  J E Seegmiller
Journal:  J Inherit Metab Dis       Date:  1989       Impact factor: 4.982

Review 3.  Management of Self-injurious Behaviors in Children with Neurodevelopmental Disorders: A Pharmacotherapy Overview.

Authors:  Ashley Sabus; James Feinstein; Patrick Romani; Edward Goldson; Allison Blackmer
Journal:  Pharmacotherapy       Date:  2019-03-27       Impact factor: 4.705

4.  Description of the Molecular and Phenotypic Spectrum of Lesch-Nyhan Disease in Eight Chinese Patients.

Authors:  Lu Li; Xiaohui Qiao; Fei Liu; Jingjing Wang; Huijun Shen; Haidong Fu; Jian-Hua Mao
Journal:  Front Genet       Date:  2022-04-26       Impact factor: 4.772

Review 5.  Uric acid biosynthesis and its disorders.

Authors:  R W Watts
Journal:  J R Coll Physicians Lond       Date:  1976-10
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.