The regulation of the immune response to T-independent antigens by prostaglandins and B cells.

The effect of inhibitors of prostaglandin synthesis on the in vitro primary immune response to two T-independent antigens has been investigated. The results, with PVP or DNP-Ficoll, suggest that the prostaglandins play an important role in the regulation of the immune response to these antigens. Furthermore, it appears that B cells may be involved in their own regulation by synthesizing and responding to prostaglandins. Although it has been previously established that T cells exert a regulatory influence on the response to PVP and DNP-Ficoll, this is the first demonstration of an apparent B cell regulation of B cell function via the production of a specific hormone.