The effect of clebopride-simethicone combination therapy on echographic visualization of retrogastric organs.

The main objective of this study was to determine whether the effect of a combination of clebopride (0.5 mg) and simethicone (200 mg) would improve echographic visualization of retrogastric organs. An experimental aerogastric induction model was used in 50 healthy volunteers, who received 30 mL of beaten egg white to decrease the quality of echographic visualization. Improvements were evaluated after treatment. The results show that the combination of clebopride and simethicone was better than placebo in reducing gastric distension and in improving the quality of echographic images of the organs located behind the stomach, that is, the gallbladder, pancreas, and left kidney.