BACKGROUND: Hereditary ovarian cancer may be site specific or may appear in combination with breast cancer or other cancers in a family. The most common hereditary form is the breast-ovarian cancer syndrome. It is estimated that in 100% of these families, there is linkage to a cancer susceptibility gene on chromosome 17q, BRCA1. METHODS: A positive family history of breast or ovarian cancer was reported for 71 of 450 unselected cases of ovarian cancer identified in Southern Ontario. Detailed pedigrees were completed by telephone interview for 48 of the 71 subjects. RESULTS: Nine families were identified with five or more cases of breast or ovarian cancer, 14 families with four cases of cancer, and eight families with three cases. Breast cancer appeared in 80% of the ovarian cancer families. There were 81 healthy first-degree female relatives of the cancer cases considered to be at high risk for ovarian cancer. CONCLUSIONS: It is feasible to use a simple questionnaire on all incident cases of ovarian cancer in a population to identify families with potential hereditary breast-ovarian cancer. Two point nine percent to 6.9% of cases of ovarian cancer appear to be inherited; the majority of the families also will have an excess number of cases of breast cancer.
BACKGROUND:Hereditary ovarian cancer may be site specific or may appear in combination with breast cancer or other cancers in a family. The most common hereditary form is the breast-ovarian cancer syndrome. It is estimated that in 100% of these families, there is linkage to a cancer susceptibility gene on chromosome 17q, BRCA1. METHODS: A positive family history of breast or ovarian cancer was reported for 71 of 450 unselected cases of ovarian cancer identified in Southern Ontario. Detailed pedigrees were completed by telephone interview for 48 of the 71 subjects. RESULTS: Nine families were identified with five or more cases of breast or ovarian cancer, 14 families with four cases of cancer, and eight families with three cases. Breast cancer appeared in 80% of the ovarian cancer families. There were 81 healthy first-degree female relatives of the cancer cases considered to be at high risk for ovarian cancer. CONCLUSIONS: It is feasible to use a simple questionnaire on all incident cases of ovarian cancer in a population to identify families with potential hereditary breast-ovarian cancer. Two point nine percent to 6.9% of cases of ovarian cancer appear to be inherited; the majority of the families also will have an excess number of cases of breast cancer.
Authors: Th E M Crijnen; M L G Janssen-Heijnen; H Gelderblom; J Morreau; M A Nooij; G G Kenter; H F A Vasen Journal: Fam Cancer Date: 2005 Impact factor: 2.375
Authors: R Moslehi; W Chu; B Karlan; D Fishman; H Risch; A Fields; D Smotkin; Y Ben-David; J Rosenblatt; D Russo; P Schwartz; N Tung; E Warner; B Rosen; J Friedman; J S Brunet; S A Narod Journal: Am J Hum Genet Date: 2000-03-16 Impact factor: 11.025
Authors: S A Narod; D Ford; P Devilee; R B Barkardottir; H T Lynch; S A Smith; B A Ponder; B L Weber; J E Garber; J M Birch Journal: Am J Hum Genet Date: 1995-01 Impact factor: 11.025
Authors: Linda E Kelemen; Kathryn L Terry; Marc T Goodman; Penelope M Webb; Elisa V Bandera; Valerie McGuire; Mary Anne Rossing; Qinggang Wang; Ed Dicks; Jonathan P Tyrer; Honglin Song; Jolanta Kupryjanczyk; Agnieszka Dansonka-Mieszkowska; Joanna Plisiecka-Halasa; Agnieszka Timorek; Usha Menon; Aleksandra Gentry-Maharaj; Simon A Gayther; Susan J Ramus; Steven A Narod; Harvey A Risch; John R McLaughlin; Nadeem Siddiqui; Rosalind Glasspool; James Paul; Karen Carty; Jacek Gronwald; Jan Lubiński; Anna Jakubowska; Cezary Cybulski; Lambertus A Kiemeney; Leon F A G Massuger; Anne M van Altena; Katja K H Aben; Sara H Olson; Irene Orlow; Daniel W Cramer; Douglas A Levine; Maria Bisogna; Graham G Giles; Melissa C Southey; Fiona Bruinsma; Susanne K Kjaer; Estrid Høgdall; Allan Jensen; Claus K Høgdall; Lene Lundvall; Svend-Aage Engelholm; Florian Heitz; Andreas du Bois; Philipp Harter; Ira Schwaab; Ralf Butzow; Heli Nevanlinna; Liisa M Pelttari; Arto Leminen; Pamela J Thompson; Galina Lurie; Lynne R Wilkens; Diether Lambrechts; Els Van Nieuwenhuysen; Sandrina Lambrechts; Ignace Vergote; Jonathan Beesley; Peter A Fasching; Matthias W Beckmann; Alexander Hein; Arif B Ekici; Jennifer A Doherty; Anna H Wu; Celeste L Pearce; Malcolm C Pike; Daniel Stram; Jenny Chang-Claude; Anja Rudolph; Thilo Dörk; Matthias Dürst; Peter Hillemanns; Ingo B Runnebaum; Natalia Bogdanova; Natalia Antonenkova; Kunle Odunsi; Robert P Edwards; Joseph L Kelley; Francesmary Modugno; Roberta B Ness; Beth Y Karlan; Christine Walsh; Jenny Lester; Sandra Orsulic; Brooke L Fridley; Robert A Vierkant; Julie M Cunningham; Xifeng Wu; Karen Lu; Dong Liang; Michelle A T Hildebrandt; Rachel Palmieri Weber; Edwin S Iversen; Shelley S Tworoger; Elizabeth M Poole; Helga B Salvesen; Camilla Krakstad; Line Bjorge; Ingvild L Tangen; Tanja Pejovic; Yukie Bean; Melissa Kellar; Nicolas Wentzensen; Louise A Brinton; Jolanta Lissowska; Montserrat Garcia-Closas; Ian G Campbell; Diana Eccles; Alice S Whittemore; Weiva Sieh; Joseph H Rothstein; Hoda Anton-Culver; Argyrios Ziogas; Catherine M Phelan; Kirsten B Moysich; Ellen L Goode; Joellen M Schildkraut; Andrew Berchuck; Paul D P Pharoah; Thomas A Sellers; Angela Brooks-Wilson; Linda S Cook; Nhu D Le Journal: Mol Nutr Food Res Date: 2014-07-28 Impact factor: 5.914
Authors: Linda E Kelemen; Elisa V Bandera; Kathryn L Terry; Mary Anne Rossing; Louise A Brinton; Jennifer A Doherty; Roberta B Ness; Susanne Krüger Kjaer; Jenny Chang-Claude; Martin Köbel; Galina Lurie; Pamela J Thompson; Michael E Carney; Kirsten Moysich; Robert Edwards; Clare Bunker; Allan Jensen; Estrid Høgdall; Daniel W Cramer; Allison F Vitonis; Sara H Olson; Melony King; Urmila Chandran; Jolanta Lissowska; Montserrat Garcia-Closas; Hannah Yang; Penelope M Webb; Joellen M Schildkraut; Marc T Goodman; Harvey A Risch Journal: BMC Cancer Date: 2013-01-22 Impact factor: 4.430