| Literature DB >> 7922544 |
T Yamamoto1, S Kakehata, T Saito, H Saito, N Akaike.
Abstract
The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.Entities:
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Year: 1994 PMID： 7922544 DOI： 10.1016/0006-8993(94)91130-4
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252