Literature DB >> 7922518

Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain.

Y Kuroda1, Y Watanabe, D S Albeck, N B Hastings, B S McEwen.   

Abstract

We evaluated the effects of adrenalectomy (ADX) and replacement with glucocorticoid receptor agonists on serotonin (5-HT) 5-HT1A and 5-HT2 receptor binding in rat brain. 5-HT1A receptor binding was increased in the CA2-CA4 and the dentate gyrus of the hippocampus 1 week after ADX. This effect was prevented by the systemic administration of aldosterone (10 micrograms/microliters/h) but not by RU28362 (10 micrograms/microliters/h). No significant effect was observed on 5-HT2 receptor binding in rat cortex. The expression of 5-HT transporter mRNA was unchanged in the raphe nucleus as measured by in situ hybridization.

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Year:  1994        PMID： 7922518     DOI： 10.1016/0006-8993(94)91916-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Corticosteroids influence the action potential firing pattern of hippocampal subfield CA3 pyramidal cells.

Authors:  D Y Okuhara; S G Beck
Journal:  Neuroendocrinology       Date:  1998-01       Impact factor: 4.914

2.  Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy.

Authors:  Melissa Lingis; Elaine Richards; Dana Perrone; Maureen Keller-Wood
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-02-28       Impact factor: 4.310

3.  Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala.

Authors:  Richard G Hunter; Rudy Bellani; Erik Bloss; Ana Costa; Russell D Romeo; Bruce S McEwen
Journal:  Brain Res       Date:  2007-03-20       Impact factor: 3.252

4.  Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat.

Authors:  Guo-Jen Huang; Joe Herbert
Journal:  Neuropsychopharmacology       Date:  2005-02       Impact factor: 7.853

Review 5.  Cognition in mania and depression: psychological models and clinical implications.

Authors:  Samuel R Chamberlain; Barbara J Sahakian
Journal:  Curr Psychiatry Rep       Date:  2004-12       Impact factor: 5.285

6.  Effects of prenatal ethanol exposure on regulation of basal hypothalamic-pituitary-adrenal activity and hippocampal 5-HT1A receptor mRNA levels in female rats across the estrous cycle.

Authors:  J H Sliwowska; N Lan; F Yamashita; A G Halpert; V Viau; J Weinberg
Journal:  Psychoneuroendocrinology       Date:  2008-07-30       Impact factor: 4.905

7.  Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.

Authors:  Julie G Hensler; Miriam A Vogt; Peter Gass
Journal:  Psychoneuroendocrinology       Date:  2009-09-18       Impact factor: 4.905

Review 8.  Corticosteroid-serotonin interactions in depression: a review of the human evidence.

Authors:  Richard J Porter; Peter Gallagher; Stuart Watson; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

9.  Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress.

Authors:  Nathalie M Goodfellow; Madhurima Benekareddy; Vidita A Vaidya; Evelyn K Lambe
Journal:  J Neurosci       Date:  2009-08-12       Impact factor: 6.167

Review 10.  The neuropsychology of mood disorders.

Authors:  Samuel R Chamberlain; Barbara J Sahakian
Journal:  Curr Psychiatry Rep       Date:  2006-12       Impact factor: 5.285
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