Literature DB >> 7922382

Combinatorial libraries. Finding the needle in the haystack.

R A Houghten1.   

Abstract

Combinatorial libraries are at the forefront of a revolution in basic research and drug discovery. They allow highly active compounds to be selected from hundreds of millions of others on the basis of biological activity.

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Year:  1994        PMID： 7922382     DOI： 10.1016/s0960-9822(00)00127-5

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  6 in total

Review 1.  Insights into the evolution of lanthipeptide biosynthesis.

Authors:  Yi Yu; Qi Zhang; Wilfred A van der Donk
Journal:  Protein Sci       Date:  2013-09-18       Impact factor: 6.725

2.  Design and synthesis of biologically active peptides: a 'tail' of amino acids can modulate activity of synthetic cyclic peptides.

Authors:  Alberto Bryan; Leroy Joseph; James A Bennett; Herbert I Jacobson; Thomas T Andersen
Journal:  Peptides       Date:  2011-10-12       Impact factor: 3.750

3.  Marine natural products: a new wave of drugs?

Authors:  Rana Montaser; Hendrik Luesch
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

4.  Xanthines as a scaffold for molecular diversity.

Authors:  G Heizmann; A N Eberle
Journal:  Mol Divers       Date:  1997       Impact factor: 2.943

5.  Combinatorial thinking in chemistry and biology.

Authors:  J Ellman; B Stoddard; J Wells
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

6.  A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.

Authors:  Rachel M Sammons; Nicole A Perry; Yangmei Li; Eun Jeong Cho; Andrea Piserchio; Diana P Zamora-Olivares; Ranajeet Ghose; Tamer S Kaoud; Ginamarie Debevec; Chandra Bartholomeusz; Vsevolod V Gurevich; Tina M Iverson; Marc Giulianotti; Richard A Houghten; Kevin N Dalby
Journal:  ACS Chem Biol       Date:  2019-05-13       Impact factor: 5.100
  6 in total

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