L Saporta1, A Yuksel. 1. Department of Urology, Sisli Etfal Teaching (Children) Hospital, Istanbul, Turkey.
Abstract
OBJECTIVE: To assess the incidence of testicular atrophy by evaluation of hormonal status, testicular histology and sperm production in chronic lepromatous patients. PATIENTS AND METHODS: Forty-one male patients with a mean age of 39.5 years (range 16-57) were studied at the Leprosy Hospital, Istanbul, Turkey, and were compared with 15 age-matched controls with proven fertility. RESULTS: Reduced testicular size was observed in 51% and gynaecomastia in 27%. Of the 31 patients who were married, 15 were primarily or secondarily infertile. Twelve of 16 patients had oligospermia or azoospermia. The mean basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and oestradiol levels were significantly elevated and the level of testosterone significantly reduced when compared with the control group. CONCLUSION: Whenever leprosy is diagnosed patients should be informed of the need for treatment of an acute attack and the need for routine assessment of FSH, LH, testosterone and oestradiol levels to detect hypogonadism and potential infertility.
OBJECTIVE: To assess the incidence of testicular atrophy by evaluation of hormonal status, testicular histology and sperm production in chronic lepromatouspatients. PATIENTS AND METHODS: Forty-one male patients with a mean age of 39.5 years (range 16-57) were studied at the Leprosy Hospital, Istanbul, Turkey, and were compared with 15 age-matched controls with proven fertility. RESULTS: Reduced testicular size was observed in 51% and gynaecomastia in 27%. Of the 31 patients who were married, 15 were primarily or secondarily infertile. Twelve of 16 patients had oligospermia or azoospermia. The mean basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and oestradiol levels were significantly elevated and the level of testosterone significantly reduced when compared with the control group. CONCLUSION: Whenever leprosy is diagnosed patients should be informed of the need for treatment of an acute attack and the need for routine assessment of FSH, LH, testosterone and oestradiol levels to detect hypogonadism and potential infertility.
Authors: Ana Paula Vieira; Maria Ângela Bianconcini Trindade; Carla Pagliari; João Avancini; Neusa Yurico Sakai-Valente; Alberto José da Silva Duarte; Gil Benard Journal: Am J Trop Med Hyg Date: 2016-02-22 Impact factor: 2.345
Authors: David M Scollard; Celina M T Martelli; Mariane M A Stefani; Maria de Fatima Maroja; Laarni Villahermosa; Fe Pardillo; Krishna B Tamang Journal: Am J Trop Med Hyg Date: 2014-12-01 Impact factor: 2.345
Authors: Sunny H Wong; Sailesh Gochhait; Dheeraj Malhotra; Fredrik H Pettersson; Yik Y Teo; Chiea C Khor; Anna Rautanen; Stephen J Chapman; Tara C Mills; Amit Srivastava; Aleksey Rudko; Maxim B Freidin; Valery P Puzyrev; Shafat Ali; Shweta Aggarwal; Rupali Chopra; Belum S N Reddy; Vijay K Garg; Suchismita Roy; Sarah Meisner; Sunil K Hazra; Bibhuti Saha; Sian Floyd; Brendan J Keating; Cecilia Kim; Benjamin P Fairfax; Julian C Knight; Philip C Hill; Richard A Adegbola; Hakon Hakonarson; Paul E M Fine; Ramasamy M Pitchappan; Rameshwar N K Bamezai; Adrian V S Hill; Fredrik O Vannberg Journal: PLoS Pathog Date: 2010-07-01 Impact factor: 6.823
Authors: Ben Krause-Kyora; Marcel Nutsua; Lisa Boehme; Federica Pierini; Dorthe Dangvard Pedersen; Sabin-Christin Kornell; Dmitriy Drichel; Marion Bonazzi; Lena Möbus; Peter Tarp; Julian Susat; Esther Bosse; Beatrix Willburger; Alexander H Schmidt; Jürgen Sauter; Andre Franke; Michael Wittig; Amke Caliebe; Michael Nothnagel; Stefan Schreiber; Jesper L Boldsen; Tobias L Lenz; Almut Nebel Journal: Nat Commun Date: 2018-05-01 Impact factor: 14.919