Literature DB >> 7919757

Normal vaginal delivery is to be recommended for haemophilia carrier gravidae.

R Ljung1, A C Lindgren, P Petrini, L Tengborn.   

Abstract

Every child with severe or moderate haemophilia A or B, born in Sweden during the period 1970-1990, was treated in the national haemophilia register, all 117 case records being surveyed for mode of delivery and perinatal complications. Of the 117 deliveries, 13 were by caesarean section and the remaining 104 vaginal. Of the 13 caesarean sections, 2 were performed because the woman was a haemophilia carrier, the remaining 11 (5 emergency, 6 elective) for other reasons. Neonatal complications were: subgaleal or cephalic haematoma (n = 12), intracranial haemorrhage (n = 4), umbilical bleeding (n = 4), haematuria (n = 1), retro-orbital bleeding (n = 1) and abnormal bleeding after surgery, injection or venepuncture (n = 28). Of the 12 infants with subgaleal/cephalic haematoma, 10 were delivered by vacuum extraction. Seven more infants were delivered by vacuum extraction and another 11 were born without abnormal bleedings after laborious (> 24 h) delivery. Of the 4 children with intracranial haemorrhage, all were sporadic cases of haemophilia, 1 was a premature birth by caesarean section in the 27th week, I was delivered by vacuum extraction and the remaining 2 vaginally. In these 4 cases there were no sequelae or only minor ones. We conclude that the risk of serious bleeding in conjunction with normal vaginal delivery is small, but that vacuum extraction should be avoided when delivering offspring of haemophilia carriers.

Entities:  

Mesh:

Year:  1994        PMID: 7919757     DOI: 10.1111/j.1651-2227.1994.tb13090.x

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN: 0803-5253            Impact factor:   2.299


  12 in total

Review 1.  Neonatal coagulation problems.

Authors:  E A Chalmers
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2004-11       Impact factor: 5.747

2.  Intracranial haemorrhage in children and adults with haemophilia A and B: a literature review of the last 20 years.

Authors:  Raimondo De Cristofaro; Massimo Franchini
Journal:  Blood Transfus       Date:  2019-04-30       Impact factor: 3.443

Review 3.  Maternal and foetal outcomes following natural vaginal versus caesarean section (c-section) delivery in women with bleeding disorders and carriers.

Authors:  Laxminarayan Karanth; Adinegara Bl Abas
Journal:  Cochrane Database Syst Rev       Date:  2021-12-09

4.  Diagnostic and therapeutic challenges of intracranial hemorrhage in neonates with congenital hemophilia: a case report and review.

Authors:  Tammuella Chrisentery Singleton; Matthew Keane
Journal:  Ochsner J       Date:  2012

5.  A practical approach to hemophilia care in children.

Authors:  Victoria E Price; Sue Ann Hawes; Anthony Kc Chan
Journal:  Paediatr Child Health       Date:  2007-05       Impact factor: 2.253

6.  Hemophilia during pregnancy.

Authors:  Ran D Goldman; Victor Blanchette; Gideon Koren
Journal:  Can Fam Physician       Date:  2003-12       Impact factor: 3.275

7.  Updated Australian consensus statement on management of inherited bleeding disorders in pregnancy.

Authors:  Scott Dunkley; Julie A Curtin; Anthony J Marren; Robert P Heavener; Simon McRae; Jennifer L Curnow
Journal:  Med J Aust       Date:  2019-03-29       Impact factor: 7.738

8.  Mode of delivery in hemophilia: vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds.

Authors:  Nadine G Andersson; Elizabeth A Chalmers; Gili Kenet; Rolf Ljung; Anne Mäkipernaa; Hervé Chambost
Journal:  Haematologica       Date:  2019-02-21       Impact factor: 9.941

Review 9.  Maternal and foetal outcomes following natural vaginal versus caesarean section (c-section) delivery in women with bleeding disorders and carriers.

Authors:  Laxminarayan Karanth; Sachchithanantham Kanagasabai; Adinegara Bl Abas
Journal:  Cochrane Database Syst Rev       Date:  2017-08-04

10.  Management of pregnancy in a patient with severe hemophilia type a.

Authors:  Vipra Sharma; Aysha Khalid; Alice J Cohen
Journal:  AJP Rep       Date:  2012-12-31
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