Literature DB >> 7919232

Actin assembly in response to extracellular signals: role of capping proteins, thymosin beta 4 and profilin.

M F Carlier1, D Pantaloni.   

Abstract

In motile non-muscle cells, G-actin sequestering proteins, capping proteins and profilin regulate actin assembly in response to extracellular signals. The regulation of actin sequestration/assembly is performed via the control of the concentration of free G-actin at steady-state. The increase in free G-actin mediated by capping proteins results in an increased sequestration of actin. When barbed ends are uncapped upon cell stimulation, the participation of profilin-actin in filament assembly causes a decrease in free G-actin, which results in the depletion of the pool of sequestered actin and concomitant increase in the F-actin pool.

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Year:  1994        PMID： 7919232     DOI： 10.1006/scel.1994.1023

Source DB:  PubMed          Journal:  Semin Cell Biol        ISSN： 1043-4682


  14 in total

1.  Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site.

Authors:  Q He; E W Dent; K F Meiri
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

2.  Fusion between phagosomes, early and late endosomes: a role for actin in fusion between late, but not early endocytic organelles.

Authors:  Rune Kjeken; Morten Egeberg; Anja Habermann; Mark Kuehnel; Pascale Peyron; Matthias Floetenmeyer; Paul Walther; Andrea Jahraus; Hélène Defacque; Sergei A Kuznetsov; Gareth Griffiths
Journal:  Mol Biol Cell       Date:  2003-11-14       Impact factor: 4.138

3.  Actin filament barbed-end capping activity in neutrophil lysates: the role of capping protein-beta 2.

Authors:  M J DiNubile; L Cassimeris; M Joyce; S H Zigmond
Journal:  Mol Biol Cell       Date:  1995-12       Impact factor: 4.138

4.  Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility.

Authors:  M F Carlier; V Laurent; J Santolini; R Melki; D Didry; G X Xia; Y Hong; N H Chua; D Pantaloni
Journal:  J Cell Biol       Date:  1997-03-24       Impact factor: 10.539

5.  Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides.

Authors:  D A Schafer; P B Jennings; J A Cooper
Journal:  J Cell Biol       Date:  1996-10       Impact factor: 10.539

6.  Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.

Authors:  U Gottwald; R Brokamp; I Karakesisoglou; M Schleicher; A A Noegel
Journal:  Mol Biol Cell       Date:  1996-02       Impact factor: 4.138

7.  Profilin inhibits pollen tube growth through actin-binding, but not poly-L-proline-binding.

Authors:  Sylvester T McKenna; Luis Vidali; Peter K Hepler
Journal:  Planta       Date:  2004-01-08       Impact factor: 4.116

8.  The actin binding site of thymosin beta 4 mapped by mutational analysis.

Authors:  M Van Troys; D Dewitte; M Goethals; M F Carlier; J Vandekerckhove; C Ampe
Journal:  EMBO J       Date:  1996-01-15       Impact factor: 11.598

9.  Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface.

Authors:  J B Marchand; P Moreau; A Paoletti; P Cossart; M F Carlier; D Pantaloni
Journal:  J Cell Biol       Date:  1995-07       Impact factor: 10.539

10.  Effects of CapG overexpression on agonist-induced motility and second messenger generation.

Authors:  H Q Sun; K Kwiatkowska; D C Wooten; H L Yin
Journal:  J Cell Biol       Date:  1995-04       Impact factor: 10.539
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