Literature DB >> 7919169

Effects of ageing on microglia in the normal rat brain: immunohistochemical observations.

K Ogura1, M Ogawa, M Yoshida.   

Abstract

The numbers of ramified microglia stained by mouse monoclonal antibodies (OX-6 and X-42) in various regions of the brain were compared in the young (8 weeks) and aged (12 months) rats. OX-6-positive microglia increased in number with ageing, but OX-42-positive microglia did not. In both young and aged rats, the number of OX-6-positive microglia in white matter was higher than that in grey matter, but the number of OX-42-positive microglia in white matter was the same as that in grey matter. OX-42 stains microglia in both activated and resting states, whereas OX-6 stains mainly microglia in the activated state. Our findings suggest that microglia become activated with age-related changes, especially in white matter.

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Year:  1994        PMID： 7919169     DOI： 10.1097/00001756-199406020-00016

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  59 in total

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3.  The Brain's Aging Immune System.

Authors:  Wolfgang J Streit; Qing-Shan Xue
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4.  Differential effects of aging and sex on stroke induced inflammation across the lifespan.

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Journal:  Exp Neurol       Date:  2013-08-29       Impact factor: 5.330

5.  [11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat.

Authors:  Matthew D Walker; Katherine Dinelle; Rick Kornelsen; Nathan V Lee; Qing Miao; Mike Adam; Christine Takhar; Edwin Mak; Michael Schulzer; Matthew J Farrer; Vesna Sossi
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6.  Functional recovery in aging mice after experimental stroke.

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Journal:  Brain Behav Immun       Date:  2011-07-02       Impact factor: 7.217

7.  Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide.

Authors:  Y Huang; C J Henry; R Dantzer; R W Johnson; J P Godbout
Journal:  Neurobiol Aging       Date:  2007-05-31       Impact factor: 4.673

8.  eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter.

Authors:  Cory Teuscher; R W Doerge; Parley D Fillmore; Elizabeth P Blankenhorn
Journal:  Genetics       Date:  2005-11-19       Impact factor: 4.562

Review 9.  Review: microglia of the aged brain: primed to be activated and resistant to regulation.

Authors:  D M Norden; J P Godbout
Journal:  Neuropathol Appl Neurobiol       Date:  2013-02       Impact factor: 8.090

10.  Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines.

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Journal:  Brain Behav Immun       Date:  2008-09-12       Impact factor: 7.217
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