| Literature DB >> 7918678 |
I Miyazaki1, R Gaedigk, M F Hui, R K Cheung, J Morkowski, R V Rajotte, H M Dosch.
Abstract
Triggering of autoimmunity in insulin-dependent diabetes was linked to dietary bovine serum albumin (BSA). Anti-BSA antibodies from diabetes-prone rats precipitate a protein, p69, from islet cell lysates. We have used these antibodies to identify rat p69 cDNAs. Human p69 cDNA was identified by crosshybridization. The p69 coding regions show 87% nucleotide and 89% amino acid homology. Recombinant p69 is recognized by autoantibody and T cells from diabetic children.Entities:
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Year: 1994 PMID： 7918678 DOI： 10.1016/0925-4439(94)90113-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002