| Literature DB >> 7918047 |
J F Abgrall1, C Berthou, L Sensebé, C Le Niger, M Escoffre.
Abstract
In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC), compared to controls (22.5 +/- 15.4 CFU-MK); P < 0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.Entities:
Mesh：
Year: 1993 PMID： 7918047 DOI： 10.1111/j.1365-2141.1993.tb03227.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998