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Literature DB >> 7917326

Small nuclear RNAs and pre-mRNA splicing.

Abstract

Genetic and biochemical studies have recently shown that the splice sites in nuclear pre-mRNAs are aligned for the transesterification reactions through a collaboration between U5 and U6 small nuclear RNAs, which form the heart of a network of RNA-based interactions in the active spliceosome.

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Year: 1994 PMID： 7917326 DOI： 10.1016/0955-0674(94)90027-2

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

10 in total

1. Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles.

Authors: I Melcák; S Melcáková; V Kopský; J Vecerová; I Raska
Journal: Mol Biol Cell Date: 2001-02 Impact factor: 4.138

2. Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae.

Authors: B G Luukkonen; B Séraphin
Journal: RNA Date: 1998-02 Impact factor: 4.942

3. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue.

Authors: T Gross; M Lützelberger; H Weigmann; A Klingenhoff; S Shenoy; N F Käufer
Journal: Nucleic Acids Res Date: 1997-03-01 Impact factor: 16.971

4. Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae.

Authors: E M Weidenhammer; M Ruiz-Noriega; J L Woolford
Journal: Mol Cell Biol Date: 1997-07 Impact factor: 4.272

5. Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.

Authors: D Yan; M Ares
Journal: Mol Cell Biol Date: 1996-03 Impact factor: 4.272

10. Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.

Authors: S Teigelkamp; A J Newman; J D Beggs
Journal: EMBO J Date: 1995-06-01 Impact factor: 11.598

10 in total

Small nuclear RNAs and pre-mRNA splicing.

1. Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles.

2. Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae.

3. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue.

4. Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae.

5. Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.

6. Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs.

7. The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RNA splicing with cell cycle progression.

8. The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae.

9. Characterization of three new snRNAs from Saccharomyces cerevisiae: snR34, snR35 and snR36.

10. Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.