| Literature DB >> 7916704 |
T Kotani1, K Umeki, I Yamamoto, M Takeuchi, S Takechi, T Nakayama, S Ohtaki.
Abstract
The nucleotide (nt) sequence of the cDNA encoding mouse thyroid peroxidase (TPO) has been determined. The TPO cDNA is 3281 nt long and its open reading frame encodes a protein composed of 914 amino acids (aa), including a putative initiation Met. The mouse TPO cDNA shows 75.3, 70.8, and 93.5% homology in the coding nt sequence with human, porcine, and rat TPO cDNAs, respectively. In the aa sequence, mouse TPO shows 73.4, 68.4, and 93.9% homology with human, porcine, and rat TPOs, respectively. Specifically, the aa sequence surrounding the proximal His residue, probably essential for TPO activity, is well conserved among these four organisms.Entities:
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Year: 1993 PMID： 7916704 DOI： 10.1016/0378-1119(93)90141-o
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688