Literature DB >> 7916697

Leishmania major: characterisation and expression of a cytoplasmic stress-related protein.

S Searle1, D F Smith.   

Abstract

The DNA sequence of a single-copy gene from Leishmania major has been determined and shown to share sequence identity with eukaryotic heat shock protein-70-related genes. Conserved features of the deduced open reading frame include amino acids implicated in ATP binding and a putative calmodulin-binding domain. Antibodies generated to the recombinant fusion protein recognise a 70-kDa molecule of pI 6.0. This molecule is constitutively expressed and localises to the cytoplasm in all stages of the parasite life cycle.

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Year:  1993        PMID： 7916697     DOI： 10.1006/expr.1993.1059

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  9 in total

1.  The Hsp70/J-protein machinery of the African trypanosome, Trypanosoma brucei.

Authors:  Stephen John Bentley; Miebaka Jamabo; Aileen Boshoff
Journal:  Cell Stress Chaperones       Date:  2018-12-01       Impact factor: 3.667

Review 2.  Protein trafficking in kinetoplastid protozoa.

Authors:  C Clayton; T Häusler; J Blattner
Journal:  Microbiol Rev       Date:  1995-09

3.  High constitutive levels of heat-shock proteins in human-pathogenic parasites of the genus Leishmania.

Authors:  S Brandau; A Dresel; J Clos
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

4.  The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species.

Authors:  P Wincker; C Ravel; C Blaineau; M Pages; Y Jauffret; J P Dedet; P Bastien
Journal:  Nucleic Acids Res       Date:  1996-05-01       Impact factor: 16.971

5.  Response of Leishmania chagasi promastigotes to oxidant stress.

Authors:  M E Wilson; K A Andersen; B E Britigan
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

6.  Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169.

Authors:  Susanne Kramer; Rafael Queiroz; Louise Ellis; Helena Webb; Jörg D Hoheisel; Christine Clayton; Mark Carrington
Journal:  J Cell Sci       Date:  2008-08-19       Impact factor: 5.285

Review 7.  Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes.

Authors:  Jose M Requena; Ana M Montalvo; Jorge Fraga
Journal:  Biomed Res Int       Date:  2015-06-18       Impact factor: 3.411

8.  Trypanosoma brucei J-Protein 2 Functionally Co-Operates with the Cytosolic Hsp70 and Hsp70.4 Proteins.

Authors:  Stephen John Bentley; Aileen Boshoff
Journal:  Int J Mol Sci       Date:  2019-11-21       Impact factor: 5.923

9.  Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.

Authors:  Sima Drini; Alexis Criscuolo; Pierre Lechat; Hideo Imamura; Tomáš Skalický; Najma Rachidi; Julius Lukeš; Jean-Claude Dujardin; Gerald F Späth
Journal:  Genome Biol Evol       Date:  2016-07-02       Impact factor: 3.416
  9 in total

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