[Application of transcranial Doppler ultrasonography in the assessment of cerebrovascular reactivity studies and cerebral vascular reserve estimation in patients with focal brain injury].

Cerebrovascular reactivity and cerebrovascular reserve were studied using transcranial Doppler sonography (TCD). Investigations were carried out in acute cases--8 patients with severe head injury within 5 days after trauma and in chronic cases with brain tissue defect (12 patients), and in cases with cerebral circulation insufficiency (15 patients). In acute cases the pCO2 cerebrovascular response was studied and in chronic cases cerebrovascular reserve was estimated using acetazolamide. TCD was found suitable for local vascular reactivity disturbances determination independently in three intracranial compartments--both hemispheres and infratentorial space. In patients with local brain tissue defect cerebrovascular reserve remained within normal range. In cerebral circulation insufficiency vascular reserve disturbances were limited to one compartment in cases with local vascular lesion they were found in all three compartments in cases with generalized atheromatosis.