| Literature DB >> 7915989 |
L La Mantia1, M Eoli, C Milanese, A Salmaggi, A Dufour, V Torri.
Abstract
The efficacy of dexamethasone (DX) and methylprednisolone (MP) at high (HD) and low (LD) dose in acute multiple sclerosis (MS) relapses was evaluated by a double-blind trial in 31 patients followed for 1 year. DX and HDMP were similarly efficacious in promoting recovery, while LDMP was ineffective in the short-term outcome and was followed by an early clinical reactivation. The different outcomes seem to be related to different immunomodulating effects, mainly on cerebrospinal fluid (CSF) IgG synthesis and on peripheral blood and CSF CD4+ lymphocyte subsets.Entities:
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Year: 1994 PMID： 7915989 DOI： 10.1159/000117038
Source DB: PubMed Journal: Eur Neurol ISSN： 0014-3022 Impact factor: 1.710