| Literature DB >> 7915606 |
Abstract
A new mutant rat strain with movement disorders has arisen spontaneously in a closed colony of Albino-Swiss rats at the Department of Anatomy, Glasgow University. The animals possess a progressive locomotor disorder which is first apparent at around post-natal day 10. We here report that tyrosine hydroxylase immunocytochemistry demonstrates that these mutants have profound depletions in dopaminergic systems in the substantia nigra and corresponding areas of neostriatum.Entities:
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Year: 1994 PMID： 7915606 DOI： 10.1111/j.1460-9568.1994.tb01000.x
Source DB: PubMed Journal: Eur J Neurosci ISSN： 0953-816X Impact factor: 3.386