Literature DB >> 7915193

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

G Jedlitschky1, I Leier, U Buchholz, M Center, D Keppler.   

Abstract

The ATP-dependent transport of the endogenous glutathione conjugate leukotriene C4 (LTC4) was more than 25-fold higher in membrane vesicles prepared from human leukemia cells (HL60/ADR) overexpressing the multidrug resistance-associated protein than from drug-sensitive parental HL60 cells or revertant cells. Similar results were obtained with S-(2,4-dinitrophenyl)glutathione as substrate. Photoaffinity labeling detected preferentially in the HL60/ADR membranes a 190-kilodalton protein binding [3H]LTC4 and 8-azido[alpha-32P]ATP. The [3H]LTC4-labeled 190-kilodalton protein was immunoprecipitated by an antiserum against the COOH-terminal sequence of multidrug resistance-associated protein. Our results indicate that multidrug resistance-associated protein mediates the ATP-dependent transport of LTC4 and structurally related anionic amphiphilic conjugates.

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Year:  1994        PMID： 7915193

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  71 in total

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Authors:  S Paul; L M Breuninger; K D Tew; H Shen; G D Kruh
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3.  The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.

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4.  Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2.

Authors:  Heather M Brechbuhl; Neal Gould; Remy Kachadourian; Wayne R Riekhof; Dennis R Voelker; Brian J Day
Journal:  J Biol Chem       Date:  2010-03-23       Impact factor: 5.157

5.  The hydroxyl group of S685 in Walker A motif and the carboxyl group of D792 in Walker B motif of NBD1 play a crucial role for multidrug resistance protein folding and function.

Authors:  Runying Yang; Robert Scavetta; Xiu-Bao Chang
Journal:  Biochim Biophys Acta       Date:  2007-11-29

6.  A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule?

Authors:  S Gupta; S Aggarwal; S Nakamura
Journal:  J Clin Immunol       Date:  1998-07       Impact factor: 8.317

7.  The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.

Authors:  Glen Reid; Peter Wielinga; Noam Zelcer; Ingrid van der Heijden; Annemieke Kuil; Marcel de Haas; Jan Wijnholds; Piet Borst
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-30       Impact factor: 11.205

8.  Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

Authors:  G J Zaman; J Lankelma; O van Tellingen; J Beijnen; H Dekker; C Paulusma; R P Oude Elferink; F Baas; P Borst
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

9.  Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

Authors:  R Mukhopadhyay; S Dey; N Xu; D Gage; J Lightbody; M Ouellette; B P Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

10.  Tissue distribution of the multidrug resistance protein.

Authors:  M J Flens; G J Zaman; P van der Valk; M A Izquierdo; A B Schroeijers; G L Scheffer; P van der Groep; M de Haas; C J Meijer; R J Scheper
Journal:  Am J Pathol       Date:  1996-04       Impact factor: 4.307
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