Literature DB >> 7914827

A novel cancer predisposition syndrome in the Eker rat model.

O Hino1, H Mitani, H Katsuyama, Y Kubo.   

Abstract

Hereditary renal carcinomas (RCs) develop in virtually all Eker rats by the age of one year. Investigation of extrarenal primary tumors occurring in Eker rats late in life (at 2 years) additionally revealed pituitary adenomas (17/31 = 54.8% (carrier) vs 7/32 = 21.9% (non-carrier siblings of affected animals), P < 0.01), sarcomas of the spleen (21/31 = 67.7% vs. 0/32 = 0%, P < 0.001) and sarcomas (of probable stromal origin) of the uterus (8/17 = 47.1% vs. 0/15 = 0%, P < 0.01). Thus, the Eker rat might provide a novel animal model of cancer predisposition syndromes.

Entities:  

Mesh：

Year:  1994        PMID： 7914827     DOI： 10.1016/0304-3835(94)90307-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  11 in total

1.  A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.

Authors:  T Kobayashi; O Minowa; Y Sugitani; S Takai; H Mitani; E Kobayashi; T Noda; O Hino
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

2.  Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development.

Authors:  G Rennebeck; E V Kleymenova; R Anderson; R S Yeung; K Artzt; C L Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

3.  Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene.

Authors:  T Kobayashi; H Mitani; R Takahashi; M Hirabayashi; M Ueda; H Tamura; O Hino
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

Review 4.  Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.

Authors:  Arno E Commandeur; Aaron K Styer; Jose M Teixeira
Journal:  Hum Reprod Update       Date:  2015-07-03       Impact factor: 15.610

5.  Isolation of microdissection clones from rat chromosome 10.

Authors:  T Kobayashi; T Kawaguchi; T Kishino; N Matsumoto; N Niikawa; M Mori; G Levan; K Klinga-Levan; O Hino
Journal:  Mamm Genome       Date:  1995-03       Impact factor: 2.957

6.  Renal carcinogenesis in the Eker rat.

Authors:  O Hino; E Kobayashi; M Nishizawa; Y Kubo; T Kobayashi; Y Hirayama; S Takai; Y Kikuchi; H Tsuchiya; K Orimoto
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

7.  cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.

Authors:  T Kobayashi; M Nishizawa; Y Hirayama; E Kobayashi; O Hino
Journal:  Nucleic Acids Res       Date:  1995-07-25       Impact factor: 16.971

8.  Rodent model of reproductive tract leiomyomata. Clinical and pathological features.

Authors:  J I Everitt; D C Wolf; S R Howe; T L Goldsworthy; C Walker
Journal:  Am J Pathol       Date:  1995-06       Impact factor: 4.307

9.  Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.

Authors:  Y Kubo; Y Kikuchi; H Mitani; E Kobayashi; T Kobayashi; O Hino
Journal:  Jpn J Cancer Res       Date:  1995-09

10.  Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes.

Authors:  S Toyokuni; K Okada; S Kondo; H Nishioka; T Tanaka; Y Nishiyama; O Hino; H Hiai
Journal:  Jpn J Cancer Res       Date:  1998-08
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