Literature DB >> 7914031

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans.

R Quiring1, U Walldorf, U Kloter, W J Gehring.   

Abstract

A Drosophila gene that contains both a paired box and a homeobox and has extensive sequence homology to the mouse Pax-6 (Small eye) gene was isolated and mapped to chromosome IV in a region close to the eyeless locus. Two spontaneous mutations, ey2 and eyR, contain transposable element insertions into the cloned gene and affect gene expression, particularly in the eye primordia. This indicates that the cloned gene encodes ey. The finding that ey of Drosophila, Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development.

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Year:  1994        PMID: 7914031     DOI: 10.1126/science.7914031

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  257 in total

1.  Regional expression of the rice KN1-type homeobox gene family during embryo, shoot, and flower development.

Authors:  N Sentoku; Y Sato; N Kurata; Y Ito; H Kitano; M Matsuoka
Journal:  Plant Cell       Date:  1999-09       Impact factor: 11.277

2.  Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians.

Authors:  D Pineda; J Gonzalez; P Callaerts; K Ikeo; W J Gehring; E Salo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

3.  Notch signaling and the determination of appendage identity.

Authors:  S Kurata; M J Go; S Artavanis-Tsakonas; W J Gehring
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

4.  Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.

Authors:  T A Heanue; R Reshef; R J Davis; G Mardon; G Oliver; S Tomarev; A B Lassar; C J Tabin
Journal:  Genes Dev       Date:  1999-12-15       Impact factor: 11.361

5.  Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.

Authors:  J I Kim; T Li; I C Ho; M J Grusby; L H Glimcher
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

6.  Six3 overexpression initiates the formation of ectopic retina.

Authors:  F Loosli; S Winkler; J Wittbrodt
Journal:  Genes Dev       Date:  1999-03-15       Impact factor: 11.361

7.  Expression of evolutionarily conserved eye specification genes during Drosophila embryogenesis.

Authors:  J P Kumar; K Moses
Journal:  Dev Genes Evol       Date:  2001-09       Impact factor: 0.900

8.  Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye.

Authors:  Todd H Oakley; Clifford W Cunningham
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

9.  The eyeless homeodomain is dispensable for eye development in Drosophila.

Authors:  C Punzo; S Kurata; W J Gehring
Journal:  Genes Dev       Date:  2001-07-01       Impact factor: 11.361

10.  Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies.

Authors:  Yasuko Onuma; Shuji Takahashi; Makoto Asashima; Shoichiro Kurata; Walter J Gehring
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

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