Literature DB >> 7913839

[Induction of autoantibodies to serotonin and catecholamines in chronically morphine addicted rats with manifestations of abstinence syndrome].

L A Basharova, V A Evseev, L A Vetrilé, N A Trekova, N B Gamaleia, A G Veretinskaia, S I Tronnikov.   

Abstract

The possibility of formation of autoantibodies to neurotransmitters has been studied in experimental model of opiate addiction. Chronic treatment of rats with morphine that leads to formation of dependence, causes induction of antibodies to norepinephrine, dopamine and serotonin. The latter could be considered as indicators of impaired neurotransmitter metabolism. Induction of autoantibodies to neurotransmitters could be a sort of defence mechanism in opiate addiction.

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Year:  1993        PMID： 7913839

Source DB:  PubMed          Journal:  Biull Eksp Biol Med        ISSN： 0365-9615


  2 in total

1.  Antibodies to dopamine as neuromodulators of behavioral responses of mice of different genotypes.

Authors:  V A Evseev; O I Mikovskaya; L A Vetrilé; N A Trekova; L A Basharova; T G Khlopushina; M A Gruden'
Journal:  Neurosci Behav Physiol       Date:  2003-06

2.  Immunization of rats with conjugates of dopamine and serotonin with bovine serum albumin prevents the development of experimental MPTP-induced depressive syndrome (electrophysiological parameters).

Authors:  N B Pankova; L A Vetrilé; L A Basharova; N A Krupina; N N Khlebnikova; V I Rodina; G N Kryzhanovskii
Journal:  Neurosci Behav Physiol       Date:  2004-02
  2 in total

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