Literature DB >> 7913744

Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) and its binding sites in the rat brain.

Y Masuo1, F Tokito, Y Matsumoto, N Shimamoto, M Fujino.   

Abstract

Endogenous levels of pituitary adenylate cyclase-activating polypeptide (PACAP) and its binding site densities were measured in eight brain regions in rats of different ages (2-240 days) by sandwich-enzyme immunoassay and autoradiography. PACAP levels were quite low at day 2, peaked in 30-60 days, and then remained constant in most regions. Such ontogenetic changes are similar to those of vasoactive intestinal polypeptide (VIP) and classical neurotransmitters. PACAP-binding sites were already dense at day 2 and varied only slightly up to day 240. These results suggest that PACAP may have modulatory effects on brain development.

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Year:  1994        PMID： 7913744     DOI： 10.1016/0304-3940(94)90234-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

1.  PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.

Authors:  Dwayne Brown; Andrea Tamas; Dora Reglödi; Yousef Tizabi
Journal:  J Mol Neurosci       Date:  2013-04-28       Impact factor: 3.444

2.  Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult.

Authors:  David Vaudry; Carol Hamelink; Ruslan Damadzic; Robert L Eskay; Bruno Gonzalez; Lee E Eiden
Journal:  Peptides       Date:  2005-07-11       Impact factor: 3.750

3.  Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.

Authors:  D Vaudry; B J Gonzalez; M Basille; A Fournier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

Review 4.  PACAP, an autocrine/paracrine regulator of gonadotrophs.

Authors:  Stephen J Winters; Joseph P Moore
Journal:  Biol Reprod       Date:  2010-12-29       Impact factor: 4.285

5.  Specific antibody recognition of rat pituitary adenylate cyclase activating polypeptide receptors.

Authors:  M Li; S Shioda; A Somogyvári-Vigh; H Onda; A Arimura
Journal:  Endocrine       Date:  1997-10       Impact factor: 3.633

6.  The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.

Authors:  D Vaudry; B J Gonzalez; M Basille; T F Pamantung; M Fontaine; A Fournier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

Review 7.  Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases.

Authors:  Agnieszka Dejda; Valérie Jolivel; Steve Bourgault; Tommy Seaborn; Alain Fournier; Hubert Vaudry; David Vaudry
Journal:  J Mol Neurosci       Date:  2008-05-28       Impact factor: 3.444

Review 8.  Advent and recent advances in research on the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropic hormone secretion of female rats.

Authors:  Katalin Köves; Orsolya Kántor; András Lakatos; Enikő Szabó; Eszter Kirilly; Andrea Heinzlmann; Flóra Szabó
Journal:  J Mol Neurosci       Date:  2014-04-03       Impact factor: 3.444

Review 9.  PACAP and its role in primary headaches.

Authors:  Lars Edvinsson; János Tajti; Levente Szalárdy; László Vécsei
Journal:  J Headache Pain       Date:  2018-03-09       Impact factor: 7.277

10.  Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival.

Authors:  Victor May; Eve Lutz; Christopher MacKenzie; Kristin C Schutz; Kate Dozark; Karen M Braas
Journal:  J Biol Chem       Date:  2010-01-21       Impact factor: 5.157
  10 in total

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