OBJECTIVE: To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in rheumatoid arthritis (RA). METHODS: A phase I/II, open-label, dose-escalation study of 32 patients. RESULTS: During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient. CONCLUSION: Anti-ICAM-1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RA patients.
OBJECTIVE: To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in rheumatoid arthritis (RA). METHODS: A phase I/II, open-label, dose-escalation study of 32 patients. RESULTS: During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient. CONCLUSION: Anti-ICAM-1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RApatients.
Authors: Xia Shao; Huanan Zhang; Justin R Rajian; David L Chamberland; Phillip S Sherman; Carole A Quesada; Alisa E Koch; Nicholas A Kotov; Xueding Wang Journal: ACS Nano Date: 2011-10-27 Impact factor: 15.881
Authors: Mourad Zerfaoui; Yasuhiro Suzuki; Amarjit S Naura; Chetan P Hans; Charles Nichols; A Hamid Boulares Journal: Cell Signal Date: 2007-10-12 Impact factor: 4.315
Authors: Bettina Sehnert; Harald Burkhardt; Johannes T Wessels; Agnes Schröder; Michael J May; Dietmar Vestweber; Jochen Zwerina; Klaus Warnatz; Falk Nimmerjahn; Georg Schett; Stefan Dübel; Reinhard Edmund Voll Journal: Proc Natl Acad Sci U S A Date: 2013-09-23 Impact factor: 11.205