Literature DB >> 7912928

Site selectivity in the glycation of alpha A- and alpha B-crystallins by glucose.

E C Abraham1, M Cherian, J B Smith.   

Abstract

We determined the site selectivity of glycation by glucose (glucosylation) in alpha A- and alpha B-crystallins using two independent approaches. HPLC purified 14C-glucose labeled chymotryptic peptides and affinity chromatography/HPLC purified fully glycated peptides were identified by FAB-MS. Lys 11 and 78 of alpha A-crystallin and Lys 90 and/or 92 of alpha B-crystallin were the fast reacting sites of glucosylation.

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Year:  1994        PMID： 7912928     DOI： 10.1006/bbrc.1994.1866

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Receptors for advanced glycosylation endproducts in human brain: role in brain homeostasis.

Authors:  J J Li; D Dickson; P R Hof; H Vlassara
Journal:  Mol Med       Date:  1998-01       Impact factor: 6.354

Review 2.  Mechanistic targeting of advanced glycation end-products in age-related diseases.

Authors:  Sheldon Rowan; Eloy Bejarano; Allen Taylor
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-08-29       Impact factor: 5.187

3.  Role of the specifically targeted lysine residues in the glycation dependent loss of chaperone activity of alpha A- and alpha B-crystallins.

Authors:  Edathara C Abraham; Jin Huaqian; Atya Aziz; Anbarasu Kumarasamy; Poppy Datta
Journal:  Mol Cell Biochem       Date:  2007-12-25       Impact factor: 3.396

4.  In vivo acetylation identified at lysine 70 of human lens alphaA-crystallin.

Authors:  P P Lin; R C Barry; D L Smith; J B Smith
Journal:  Protein Sci       Date:  1998-06       Impact factor: 6.725

5.  Gamma III-crystallin is the primary target of glycation in the bovine lens incubated under physiological conditions.

Authors:  Hong Yan; Antony C Willis; John J Harding
Journal:  Biochem J       Date:  2003-09-15       Impact factor: 3.857

6.  Comparison of modification sites in glycated crystallin in vitro and in vivo.

Authors:  Martyna Kielmas; Monika Kijewska; Alicja Kluczyk; Jolanta Oficjalska; Bożena Gołębiewska; Piotr Stefanowicz; Zbigniew Szewczuk
Journal:  Anal Bioanal Chem       Date:  2015-01-31       Impact factor: 4.142

Review 7.  Mass spectrometric determination of early and advanced glycation in biology.

Authors:  Naila Rabbani; Amal Ashour; Paul J Thornalley
Journal:  Glycoconj J       Date:  2016-07-20       Impact factor: 2.916

Review 8.  Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis.

Authors:  Xingjun Fan; Vincent M Monnier
Journal:  Exp Eye Res       Date:  2021-07-20       Impact factor: 3.770
  8 in total

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