Literature DB >> 7912566

The type I growth factor receptors in human breast cancer.

T Rajkumar1, W J Gullick.   

Abstract

The type 1 family of growth factor receptors includes the EGFR, c-erbB2, c-erbB3, and c-erbB4. All four members of the family are expressed in breast cancer. The EGFR gene and more frequently the c-erbB2 gene are amplified in a proportion of cases. In addition to increased expression as a result of gene amplification, overexpression of perhaps all of the receptors also appears to occur, probably as a result of increased mRNA transcription. Overexpression may have prognostic value and may predict response to current therapies. Finally these GFR proteins represent targets for new types of chemotherapeutic agents.

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Year:  1994        PMID： 7912566     DOI： 10.1007/bf00666177

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  36 in total

1.  Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.

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Journal:  Science       Date:  1989-05-12       Impact factor: 47.728

2.  Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

Authors:  F Ciardiello; N Kim; T Saeki; R Dono; M G Persico; G D Plowman; J Garrigues; S Radke; G J Todaro; D S Salomon
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

3.  HER-2/neu oncogene protein and prognosis in breast cancer.

Authors:  A K Tandon; G M Clark; G C Chamness; A Ullrich; W L McGuire
Journal:  J Clin Oncol       Date:  1989-08       Impact factor: 44.544

Review 4.  The type 1 (EGFR-related) family of growth factor receptors and their ligands.

Authors:  S A Prigent; N R Lemoine
Journal:  Prog Growth Factor Res       Date:  1992

5.  A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells.

Authors:  G K Scott; R Robles; J W Park; P A Montgomery; J Daniel; W E Holmes; J Lee; G A Keller; W L Li; B M Fendly
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

6.  An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation.

Authors:  T W Flickinger; N J Maihle; H J Kung
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

Review 7.  The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients.

Authors:  J G Klijn; P M Berns; P I Schmitz; J A Foekens
Journal:  Endocr Rev       Date:  1992-02       Impact factor: 19.871

8.  c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma--an immunocytochemical study.

Authors:  G Gasparini; W J Gullick; S Maluta; P Dalla Palma; O Caffo; E Leonardi; P Boracchi; F Pozza; N R Lemoine; P Bevilacqua
Journal:  Eur J Cancer       Date:  1994       Impact factor: 9.162

9.  Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

Authors:  M H Kraus; N C Popescu; S C Amsbaugh; C R King
Journal:  EMBO J       Date:  1987-03       Impact factor: 11.598

10.  c-erbB-2 expression in benign and malignant breast disease.

Authors:  B A Gusterson; L G Machin; W J Gullick; N M Gibbs; T J Powles; C Elliott; S Ashley; P Monaghan; S Harrison
Journal:  Br J Cancer       Date:  1988-10       Impact factor: 7.640
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  30 in total

Review 1.  Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?

Authors:  Douglas B Sawyer; Xuyang Peng; Billy Chen; Laura Pentassuglia; Chee Chew Lim
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2.  Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.

Authors:  Lei Duan; Gengsheng Chen; Sumeet Virmani; GuoGuang Ying; Srikumar M Raja; Byung Min Chung; Mark A Rainey; Manjari Dimri; Cesar F Ortega-Cava; Xiangshan Zhao; Robert J Clubb; Chun Tu; Alagarsamy L Reddi; Mayumi Naramura; Vimla Band; Hamid Band
Journal:  J Biol Chem       Date:  2009-10-13       Impact factor: 5.157

Review 3.  Estrongenic steroid hormones in lung cancer.

Authors:  Jill M Siegfried; Laura P Stabile
Journal:  Semin Oncol       Date:  2013-12-12       Impact factor: 4.929

4.  Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.

Authors:  Zhongwei Cao; Xiuli Wu; Lily Yen; Colleen Sweeney; Kermit L Carraway
Journal:  Mol Cell Biol       Date:  2007-01-08       Impact factor: 4.272

5.  Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.

Authors:  P M Siegel; E D Ryan; R D Cardiff; W J Muller
Journal:  EMBO J       Date:  1999-04-15       Impact factor: 11.598

6.  A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

Authors:  Vincent W Keng; Augusto Villanueva; Derek Y Chiang; Adam J Dupuy; Barbara J Ryan; Ilze Matise; Kevin A T Silverstein; Aaron Sarver; Timothy K Starr; Keiko Akagi; Lino Tessarollo; Lara S Collier; Scott Powers; Scott W Lowe; Nancy A Jenkins; Neal G Copeland; Josep M Llovet; David A Largaespada
Journal:  Nat Biotechnol       Date:  2009-02-22       Impact factor: 54.908

7.  Adaptive Immune Responses and HER2/neu Positive Breast Cancer.

Authors:  Eric D Mortenson; Yang-Xin Fu
Journal:  Curr Pathobiol Rep       Date:  2013-03

Review 8.  Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines.

Authors:  A E Wakeling; A J Barker; D H Davies; D S Brown; L R Green; S A Cartlidge; J R Woodburn
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

9.  Clonal selection for transcriptionally active viral oncogenes during progression to cancer.

Authors:  Brian A Van Tine; John C Kappes; N Sanjib Banerjee; Judith Knops; Lilin Lai; Renske D M Steenbergen; Chris L J M Meijer; Peter J F Snijders; Pamela Chatis; Thomas R Broker; Phillip T Moen; Louise T Chow
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

10.  Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages.

Authors:  Soner Dogan; Olga P Rogozina; Anna E Lokshin; Joseph P Grande; Margot P Cleary
Journal:  Oncol Lett       Date:  2010-01-01       Impact factor: 2.967
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