OBJECTIVES: To study if the reported association of a BamH I 2kb RFLP of the T cell receptor V beta 8 gene with DR4+ rheumatoid arthritis patients is found in non-American white populations. METHODS: The frequency of this RFLP in two different populations was analysed. Eighty one northern Italians were studied for HLA-DR genotypes and V beta 8 polymorphism, and 29 DR4+ British white patients were studied for V beta 8 polymorphism. RESULTS: No association between the V beta 8 RFLP and DR4 was found with rheumatoid arthritis in both groups. CONCLUSION: The reported V beta 8-DR4 association is not generally applicable. The lack of association in our populations may be due to genetic differences, or to differences in factors which shaped the T cell repertoire.
OBJECTIVES: To study if the reported association of a BamH I 2kb RFLP of the T cell receptor V beta 8 gene with DR4+ rheumatoid arthritispatients is found in non-American white populations. METHODS: The frequency of this RFLP in two different populations was analysed. Eighty one northern Italians were studied for HLA-DR genotypes and V beta 8 polymorphism, and 29 DR4+ British white patients were studied for V beta 8 polymorphism. RESULTS: No association between the V beta 8 RFLP and DR4 was found with rheumatoid arthritis in both groups. CONCLUSION: The reported V beta 8-DR4 association is not generally applicable. The lack of association in our populations may be due to genetic differences, or to differences in factors which shaped the T cell repertoire.
Authors: A S Rigby; A J Silman; L Voelm; J C Gregory; W E Ollier; M A Khan; G T Nepom; G Thomson Journal: Genet Epidemiol Date: 1991 Impact factor: 2.135
Authors: F C Arnett; S M Edworthy; D A Bloch; D J McShane; J F Fries; N S Cooper; L A Healey; S R Kaplan; M H Liang; H S Luthra Journal: Arthritis Rheum Date: 1988-03
Authors: N de Vries; C F Prinsen; E B Mensink; P L van Riel; M A van't Hof; L B van de Putte Journal: Ann Rheum Dis Date: 1993-05 Impact factor: 19.103
Authors: D Jaraquemada; W Ollier; J Awad; A Young; A Silman; I M Roitt; M Corbett; F Hay; J A Cosh; R N Maini Journal: Ann Rheum Dis Date: 1986-08 Impact factor: 19.103
Authors: B Gulwani-Akolkar; D N Posnett; C H Janson; J Grunewald; H Wigzell; P Akolkar; P K Gregersen; J Silver Journal: J Exp Med Date: 1991-11-01 Impact factor: 14.307