Literature DB >> 7912170

Changes in biliary (high-molecular-mass) and liver isoforms of alkaline phosphatase after baboon-to-human liver transplantation.

D Mercer1, M Tang, I R Marino, A Demetris, J Fung, T Starzl, V Warty.   

Abstract

We report a case of hyperphosphatasemia in a 35-year-old patient with hepatitis B who underwent an orthotopic xenogeneic liver transplant. Marked increases in total alkaline phosphatase (ALP; EC 3.1.3.1) activity began 5 days posttransplantation (six times human normal) and increased to approximately 17 times normal at day 11. Increased ALP persisted for > 40 days and steadily increased to 75 times normal in the patient's last 30 days. Gel electrophoresis detected both liver (LALP) and biliary (high-molecular-mass, BALP) isoforms. LALP measured with ion-exchange columns revealed an activity time course pattern similar to that of total ALP. Results for BALP activity also obtained with ion-exchange columns exhibited broad variability, ranging from 2 to 428 times normal.

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Year:  1994        PMID： 7912170      PMCID： PMC3154767     

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  15 in total

1.  Liver transplantation under cyclosporine: a decade of experience.

Authors:  R D Gordon; S Todo; A G Tzakis; J J Fung; A Stieber; S M Staschak; S Iwatsuki; T E Starzl
Journal:  Transplant Proc       Date:  1991-02       Impact factor: 1.066

2.  Metabolism during hepatic transplantation: indicators of allograft function.

Authors:  J J Fath; N L Ascher; F N Konstantinides; J Bloomer; H Sharp; J S Najarian; F B Cerra
Journal:  Surgery       Date:  1984-10       Impact factor: 3.982

Review 3.  Evolution of liver transplantation.

Authors:  T E Starzl; S Iwatsuki; D H Van Thiel; J C Gartner; B J Zitelli; J J Malatack; R R Schade; B W Shaw; T R Hakala; J T Rosenthal; K A Porter
Journal:  Hepatology       Date:  1982 Sep-Oct       Impact factor: 17.425

4.  A comparison of a new solution combining histidine and lactobionate with UW solution and eurocollins for rat liver preservation.

Authors:  R Sumimoto; N Kamada; N V Jamieson; Y Fukuda; K Dohi
Journal:  Transplantation       Date:  1991-03       Impact factor: 4.939

5.  One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.

Authors:  S Todo; J J Fung; A Tzakis; A J Demetris; A Jain; M Alessiani; S Takaya; R Day; R Gordon; T E Starzl
Journal:  Transplant Proc       Date:  1991-02       Impact factor: 1.066

6.  Biochemical values in the normal and hypothermic baboom Papio cynocephalus/anubis.

Authors:  C F Phillips; A A Nicolalde; S K Wolfson
Journal:  J Med Primatol       Date:  1975       Impact factor: 0.667

7.  Baboon-to-human liver transplantation.

Authors:  T E Starzl; J Fung; A Tzakis; S Todo; A J Demetris; I R Marino; H Doyle; A Zeevi; V Warty; M Michaels
Journal:  Lancet       Date:  1993-01-09       Impact factor: 79.321

8.  Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients.

Authors:  A J Demetris; J J Fung; S Todo; J McCauley; A Jain; S Takaya; M Alessiani; K Abu-Elmagd; D H Van Thiel; T E Starzl
Journal:  Transplantation       Date:  1992-05       Impact factor: 4.939

9.  Lipid and apolipoprotein changes after orthotopic liver transplantation for end-stage liver diseases.

Authors:  C L Malmendier; J F Lontie; D Mathé; R Adam; H Bismuth
Journal:  Clin Chim Acta       Date:  1992-08-31       Impact factor: 3.786

10.  Liver plasma membrane: the source of high molecular weight alkaline phosphatase in human serum.

Authors:  M E De Broe; F Roels; E J Nouwen; L Claeys; R J Wieme
Journal:  Hepatology       Date:  1985 Jan-Feb       Impact factor: 17.425
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