| Literature DB >> 7912166 |
I Yoshino1, P S Goedegebuure, G E Peoples, A S Parikh, J M DiMaio, H K Lyerly, A F Gazdar, T J Eberlein.
Abstract
Previously, we have reported a correlation between the expression of HER2/neu and sensitivity to HLA-A2-restricted cytotoxic T-cells (CTL) in ovarian cancer. To investigate the role of HER2/neu in human non-small cell lung cancer (NSCLC), we established autologous tumor-specific CTL from tumor-infiltrating lymphocytes of HLA-A2+ HER2/neu+ NSCLC patients. These CTL lines specifically recognized HLA-A2+ HER2/neu+ autologous and allogeneic NSCLC cell lines as well as HLA-A2+ HER2/neu+ heterologous ovarian cancer cell lines. Furthermore, these CTL recognized an overexpressed, HER2/neu-derived peptide. From these results, we conclude that HLA-A2 serves as a restriction element in NSCLC. More importantly, at least one HER2/neu-derived peptide is a tumor-associated antigen in NSCLC and ovarian cancer.Entities:
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Year: 1994 PMID： 7912166
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701