Literature DB >> 7912160

Raphe pallidus stimulation increases gastric contractility via TRH projections to the dorsal vagal complex in rats.

T Garrick1, M Prince, H Yang, G Ohning, Y Taché.   

Abstract

The role of thyrotropin releasing hormone (TRH) in the dorsal vagal complex (DVC) in mediating the enhanced gastric contractility induced by glutamate (100 pmol) microinjected into the raphe pallidus (Rpa) was investigated in urethane-anesthetized rats acutely implanted with miniature strain gauge force transducers on the corpus of the stomach. Glutamate-induced stimulation of gastric contractility was dose-dependently inhibited by bilateral microinjection into the DVC of TRH antibody (0.17, 0.85 or 1.7 micrograms/100 nl/site) but not by vehicle. TRH antibody microinjected into the dorsal medullary reticular field had no effect. These data indicate that activation of Rpa neurons by glutamate increases gastric motor function through TRH release in the DVC.

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Year:  1994        PMID： 7912160     DOI： 10.1016/0006-8993(94)91035-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Characterization of the in vitro effects of 5-hydroxytryptamine (5-HT) on identified neurones of the rat dorsal motor nucleus of the vagus (DMV).

Authors:  K N Browning; R A Travagli
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Review 2.  Brain-gut axis of the liver: the role of central neuropeptides.

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Journal:  J Gastroenterol       Date:  2002-11       Impact factor: 7.527

3.  Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats.

Authors:  Ying Cao; Yutaka Fujito; Kiyoji Matsuyama; Mamoru Aoki
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2006-01-11       Impact factor: 1.836

Review 4.  Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Authors:  Y Taché; H Yang; M Miampamba; V Martinez; P Q Yuan
Journal:  Auton Neurosci       Date:  2006-03-06       Impact factor: 3.145

Review 5.  Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.

Authors:  Kirsteen N Browning; R Alberto Travagli
Journal:  Compr Physiol       Date:  2014-10       Impact factor: 9.090

6.  The peptide TRH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex.

Authors:  K N Browning; R A Travagli
Journal:  J Physiol       Date:  2001-03-01       Impact factor: 5.182

7.  Hypothyroidism induces Fos-like immunoreactivity in ventral medullary neurons that synthesize TRH.

Authors:  P Q Yuan; H Yang
Journal:  Am J Physiol       Date:  1999-11

8.  Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats.

Authors:  H Yang; P Q Yuan; L Wang; Y Taché
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

9.  Localization of thyroid hormone receptor beta2 in the ventral medullary neurons that synthesize thyrotropin-releasing hormone.

Authors:  P Q Yuan; H Yang
Journal:  Brain Res       Date:  2000-06-16       Impact factor: 3.252

Review 10.  Importance of medullary thyrotropin-releasing hormone in brain-gut circuits regulating gastric integrity: preclinical studies.

Authors:  Hiroshi Kaneko; Yvette Taché; Kazuo Kusugami
Journal:  J Gastroenterol       Date:  2002-11       Impact factor: 7.527
  10 in total

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