Literature DB >> 7911602

Recovery of visual response of injured adult rat optic nerves treated with transglutaminase.

S Eitan1, A Solomon, V Lavie, E Yoles, D L Hirschberg, M Belkin, M Schwartz.   

Abstract

Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with oligodendrocytes. Regeneration of central nervous system axons in fish is correlated with the presence of a transglutaminase. This enzyme dimerizes interleukin-2, and the product is cytotoxic to oligodendrocytes in vitro. Application of this nerve-derived transglutaminase to rat optic nerves, in which the injury had caused the loss of visual evoked potential response to light, promoted the recovery of that response within 6 weeks after injury. Transmission electron microscopy analysis revealed the concomitant appearance of axons in the distal stump of the optic nerve.

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Year:  1994        PMID： 7911602     DOI： 10.1126/science.7911602

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  19 in total

Review 1.  Nitric-oxide synthase and neurodegeneration/neuroprotection.

Authors:  P L Kaufman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels.

Authors:  Yo-El Ju; Paul A Janmey; Margaret E McCormick; Evelyn S Sawyer; Lisa A Flanagan
Journal:  Biomaterials       Date:  2007-01-26       Impact factor: 12.479

Review 3.  Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes.

Authors:  L Fesus
Journal:  Cell Mol Neurobiol       Date:  1998-12       Impact factor: 5.046

Review 4.  Transglutaminase induction by various cell death and apoptosis pathways.

Authors:  L Fesus; A Madi; Z Balajthy; Z Nemes; Z Szondy
Journal:  Experientia       Date:  1996-10-31

5.  Neurodegenerative diseases and transglutaminase.

Authors:  L Lorand
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

6.  Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase.

Authors:  M Raghunath; B Höpfner; D Aeschlimann; U Lüthi; M Meuli; S Altermatt; R Gobet; L Bruckner-Tuderman; B Steinmann
Journal:  J Clin Invest       Date:  1996-09-01       Impact factor: 14.808

7.  Spatiotemporal expression of postsynaptic density 95 in rat retina after optic nerve injury.

Authors:  Chen Li; Yi Zhou; ZhiQiang Liu; JingSheng Tuo; Nan Hu; HuaiJin Guan
Journal:  J Mol Neurosci       Date:  2011-09-17       Impact factor: 3.444

8.  Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosis.

Authors:  Sunando Datta; Marc A Antonyak; Richard A Cerione
Journal:  Biochemistry       Date:  2006-11-07       Impact factor: 3.162

9.  Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity.

Authors:  Francisco Velez V; Jeffrey A Romano; Robert L McKown; Kari Green; Liwen Zhang; Ronald W Raab; Denise S Ryan; Cindy M L Hutnik; Henry F Frierson; Gordon W Laurie
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-03-01       Impact factor: 4.799

10.  Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration.

Authors:  Amy T McCurley; Gloria V Callard
Journal:  J Exp Neurosci       Date:  2010-07-13
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