Literature DB >> 7911575

A D1 agonist in the MPOA facilitates copulation in male rats.

V P Markowski1, R C Eaton, L A Lumley, J Moses, E M Hull.   

Abstract

The classic dopamine agonist apomorphine, microinjected into the medial preoptic area (MPOA), enhances the copulatory behavior of male rats, while pharmacological blockade of endogenous dopamine inhibits sexual behavior. We now report that MPOA injections of 10 micrograms of the selective D1 agonist dihydroxyphenyl-tetrahydrothienopyridine (THP) significantly increased the number of ejaculations, while decreasing the latency to ejaculate in a 30-min test. These effects were not observed following coadministration of the selective D1 antagonist SCH-23390 with 10 micrograms THP. This enhancement may be related to a D1-stimulated facilitation of penile erections.

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Year:  1994        PMID： 7911575     DOI： 10.1016/0091-3057(94)90147-3

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  15 in total

1.  Regulation by the medial amygdala of copulation and medial preoptic dopamine release.

Authors:  J Dominguez; J V Riolo; Z Xu; E M Hull
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

2.  Dopamine activates noradrenergic receptors in the preoptic area.

Authors:  C A Cornil; J Balthazart; P Motte; L Massotte; V Seutin
Journal:  J Neurosci       Date:  2002-11-01       Impact factor: 6.167

3.  Differences in placentophagia in relation to reproductive status in the California mouse (Peromyscus californicus).

Authors:  Juan P Perea-Rodriguez; Wendy Saltzman
Journal:  Dev Psychobiol       Date:  2013-09-25       Impact factor: 3.038

4.  Is sexual motivational state linked to dopamine release in the medial preoptic area?

Authors:  H K Kleitz-Nelson; J M Dominguez; C A Cornil; G F Ball
Journal:  Behav Neurosci       Date:  2010-04       Impact factor: 1.912

5.  Co-localization of mu-opioid and dopamine D1 receptors in the medial preoptic area and bed nucleus of the stria terminalis across seasonal states in male European starlings.

Authors:  Jeremy A Spool; Devin P Merullo; Changjiu Zhao; Lauren V Riters
Journal:  Horm Behav       Date:  2018-11-20       Impact factor: 3.587

6.  Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.

Authors:  Jenna A McHenry; Genevieve A Bell; Bradley P Parrish; Elaine M Hull
Journal:  Behav Neurosci       Date:  2012-06-18       Impact factor: 1.912

7.  Differential relationships between D1 and D2 dopamine receptor expression in the medial preoptic nucleus and sexually-motivated song in male European starlings (Sturnus vulgaris).

Authors:  M S DeVries; M A Cordes; S A Stevenson; L V Riters
Journal:  Neuroscience       Date:  2015-06-12       Impact factor: 3.590

8.  Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings.

Authors:  Lauren V Riters; Benjamin A Pawlisch; Cynthia A Kelm-Nelson; Sharon A Stevenson
Journal:  Eur J Neurosci       Date:  2013-11-28       Impact factor: 3.386

9.  Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling.

Authors:  Christopher L Wright; Margaret M McCarthy
Journal:  J Neurosci       Date:  2009-10-21       Impact factor: 6.167

Review 10.  The effects of early life stress on motivated behaviors: A role for gonadal hormones.

Authors:  Samantha R Eck; Debra A Bangasser
Journal:  Neurosci Biobehav Rev       Date:  2020-10-03       Impact factor: 8.989
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