| Literature DB >> 7911330 |
Abstract
Transport of the carcinogen benzo[a]pyrene in apical membrane vesicles (AMV) from normal human intestine, was investigated. Benzo[a]pyrene transport was found in AMV throughout the small intestine, but was greatest in colon. Evidence suggesting involvement of P-Glycoprotein (P-Gp), included (1) comparable transport of P-Gp substrate doxorubicin, (2) transport stimulation by ATP and (3) transport suppression by the P-Gp inhibitor, verapamil.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7911330 DOI： 10.1016/0925-4439(94)90034-5
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002