| Literature DB >> 7910974 |
R Ganguli1, Z Yang, G Shurin, K N Chengappa, J S Brar, A V Gubbi, B S Rabin.
Abstract
Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (r = 0.32, p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.Entities:
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Year: 1994 PMID： 7910974 DOI： 10.1016/0165-1781(94)90042-6
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222