Literature DB >> 791095

Dual-action cephalosporin utilizing a novel therapeutic principle.

D Greenwood, F O'Grady.   

Abstract

A new cephalosporin is described that overcomes, in a novel way, the general susceptibility of this group of agents to enterobacterial beta-lactamases. The new compound carries a substituent that is released on cleavage of the beta-lactam ring and then exhibits antibacterial activity in its own right. The possible therapeutic benefits of such an antibiotic are discussed.

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Year:  1976        PMID： 791095      PMCID： PMC429730          DOI： 10.1128/AAC.10.2.249

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Response of ampicillin resistant Escherichia coli to cephalosporins in an in vitro model simulating conditions of bacterial growth in the urinary bladder.

Authors:  D Greenwood; F O'Grady
Journal:  Br J Exp Pathol       Date:  1975-04

2.  Resistance categories of enterobacteria to beta-lactam antibiotics.

Authors:  D Greenwood; F O'Grady
Journal:  J Infect Dis       Date:  1975-09       Impact factor: 5.226

3.  Activity of cefazolin against dense populations of enterobacteria.

Authors:  D Greenwood; C H Chan-Teoh; F O'Grady
Journal:  Antimicrob Agents Chemother       Date:  1975-02       Impact factor: 5.191

4.  A new cephalosporin with a dual mode of action.

Authors:  C H O'Callaghan; R B Sykes; S E Staniforth
Journal:  Antimicrob Agents Chemother       Date:  1976-08       Impact factor: 5.191

5.  The comparative performance of beta-lactam antibiotics against ampicillin sensitive Escherichia coli in conditions simulating those of the infected urinary bladder.

Authors:  D Greenwood; F O'Grady
Journal:  Br J Exp Pathol       Date:  1974-06

6.  Treatment of "bacterial cystitis" in fully automatic machanical models simulating conditions of bacterial growth in the urinary bladder.

Authors:  F O'Grady; I P Mackintosh; D Greenwood; B W Watson
Journal:  Br J Exp Pathol       Date:  1973-06

7.  A twelve channel bacterial growth monitoring system.

Authors:  I P Mackintosh; F O'Grady; D Greenwood; B W Watson; T C Crichton; R Piper; A Ferrer
Journal:  Biomed Eng       Date:  1973-12

8.  Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients.

Authors:  N H Steigbigel; C E McCall; C W Reed; M Finland
Journal:  Ann N Y Acad Sci       Date:  1967-09-27       Impact factor: 5.691

9.  Use and control of cephalosporins.

Authors:  S Eykyn
Journal:  J Clin Pathol       Date:  1971-07       Impact factor: 3.411

10.  Potent combinations of beta-lactam antibiotics using the beta-lactamase inhibition principle.

Authors:  D Greenwood; F O'Grady
Journal:  Chemotherapy       Date:  1975       Impact factor: 2.544
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  4 in total

1.  Antimicrobial activity of Ro 23-9424, a novel ester-linked codrug of fleroxacin and desacetylcefotaxime.

Authors:  R N Jones; A L Barry; C Thornsberry
Journal:  Antimicrob Agents Chemother       Date:  1989-06       Impact factor: 5.191

2.  In vitro activities of a dual-action antibacterial agent, Ro 23-9424, and comparative agents.

Authors:  G Beskid; V Fallat; E R Lipschitz; D H McGarry; R Cleeland; K Chan; D D Keith; J Unowsky
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

3.  Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.

Authors:  Landys Lopez Quezada; Kelin Li; Stacey L McDonald; Quyen Nguyen; Andrew J Perkowski; Cameron W Pharr; Ben Gold; Julia Roberts; Kathrine McAulay; Kohta Saito; Selin Somersan Karakaya; Prisca Elis Javidnia; Esther Porras de Francisco; Manuel Marin Amieva; Sara Palomo Dı Az; Alfonso Mendoza Losana; Matthew Zimmerman; Hsin-Pin Ho Liang; Jun Zhang; Veronique Dartois; Stéphanie Sans; Sophie Lagrange; Laurent Goullieux; Christine Roubert; Carl Nathan; Jeffrey Aubé
Journal:  ACS Infect Dis       Date:  2019-06-11       Impact factor: 5.084

4.  Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.

Authors:  Jacqueline M Zaengle-Barone; Abigail C Jackson; David M Besse; Bradford Becken; Mehreen Arshad; Patrick C Seed; Katherine J Franz
Journal:  ACS Infect Dis       Date:  2018-03-26       Impact factor: 5.084
  4 in total

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