Literature DB >> 7910780

Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons.

G B Stefano1, M Sawada, E M Smith, T K Hughes.   

Abstract

1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels in Mytilus pedal ganglia. 3. The gp120-associated decrease in DA levels in Mytilus is dose dependent and exhibits a threshold level. 4. The alteration of in vitro DA levels is specific for gp120 since anti-gp120 blocks the effect. 5. gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7910780     DOI： 10.1007/bf00711557

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  24 in total

1.  Degradation of Met-enkephalin by hemolymph peptidases in Mytilus edulis.

Authors:  M K Leung; S Le; S Houston; G B Stefano
Journal:  Cell Mol Neurobiol       Date:  1992-10       Impact factor: 5.046

Review 2.  Invertebrate and vertebrate neuroimmune and autoimmunoregulatory commonalties involving opioid peptides.

Authors:  G B Stefano
Journal:  Cell Mol Neurobiol       Date:  1992-10       Impact factor: 5.046

3.  Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.

Authors:  S Koenig; H E Gendelman; J M Orenstein; M C Dal Canto; G H Pezeshkpour; M Yungbluth; F Janotta; A Aksamit; M A Martin; A S Fauci
Journal:  Science       Date:  1986-09-05       Impact factor: 47.728

4.  High affinity dopamine binding to mouse thymocytes and Mytilus edulis (Bivalvia) hemocytes.

Authors:  G B Stefano; X H Zhao; D Bailey; M Metlay; M K Leung
Journal:  J Neuroimmunol       Date:  1989-01       Impact factor: 3.478

5.  Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

Authors:  T K Hart; R Kirsh; H Ellens; R W Sweet; D M Lambert; S R Petteway; J Leary; P J Bugelski
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

6.  Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.

Authors:  C A Wiley; R D Schrier; J A Nelson; P W Lampert; M B Oldstone
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

7.  Interaction of immunoactive monokines (interleukin 1 and tumor necrosis factor) in the bivalve mollusc Mytilus edulis.

Authors:  T K Hughes; E M Smith; R Chin; P Cadet; J Sinisterra; M K Leung; M A Shipp; B Scharrer; G B Stefano
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

8.  Ionic mechanism of inhibition of long duration in Aplysia synapse.

Authors:  M Sawada; K Enomoto; T Maeno; J E Blankenship
Journal:  J Neurosci Res       Date:  1980       Impact factor: 4.164

9.  Lipopolysaccharide and opioids activate distinct populations of Mytilus edulis immunocytes.

Authors:  T K Hughes; E M Smith; J A Barnett; R Charles; G B Stefano
Journal:  Cell Tissue Res       Date:  1991-05       Impact factor: 5.249

10.  Ionic mechanism of the outward current induced by extracellular ejection of interleukin-1 onto identified neurons of Aplysia.

Authors:  M Sawada; N Hara; T Maeno
Journal:  Brain Res       Date:  1991-04-05       Impact factor: 3.252
View more
  2 in total

1.  Preferential sensitivity of human dopaminergic neurons to gp120-induced oxidative damage.

Authors:  Shuxian Hu; Wen S Sheng; James R Lokensgard; Phillip K Peterson; R Bryan Rock
Journal:  J Neurovirol       Date:  2009-09       Impact factor: 2.643

Review 2.  Hypoxia defined as a common culprit/initiation factor in mitochondrial-mediated proinflammatory processes.

Authors:  George B Stefano; Richard M Kream
Journal:  Med Sci Monit       Date:  2015-05-22
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.