Literature DB >> 7909601

A case of narcotic bowel syndrome successfully treated with clonidine.

V Wong1, G Sobala, M Losowsky.   

Abstract

Patients with chronic abdominal pain without an organic basis present a difficult management problem. Some of these patients may be prescribed opiates initially which may result in requiring progressively higher doses for pain relief. In this clinical setting, the suspicion of narcotic bowel syndrome should be borne in mind. With appropriate treatment and counselling, further invasive investigations including laparotomy may be avoided and resolution of symptoms can be achieved with clonidine. This case report demonstrates such a typical clinical scenario and discusses the possible aetiology and pathophysiology of narcotic bowel syndrome as well as the role of clonidine in controlling opiate withdrawal symptoms.

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Year:  1994        PMID: 7909601      PMCID: PMC2397653          DOI: 10.1136/pgmj.70.820.138

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN: 0032-5473            Impact factor:   2.401


  16 in total

Review 1.  The narcotic bowel syndrome.

Authors:  M Rogers; J J Cerda
Journal:  J Clin Gastroenterol       Date:  1989-04       Impact factor: 3.062

2.  An enquiry into the incidence and prognosis of undiagnosed abdominal pain treated in hospital.

Authors:  E H Rang; A S Fairbairn; E D Acheson
Journal:  Br J Prev Soc Med       Date:  1970-02

3.  Suppression of morphine withdrawal diarrhea by clonidine.

Authors:  W A Schreier; T F Burks
Journal:  Proc West Pharmacol Soc       Date:  1981

Review 4.  Speculations on the role of motility in the pathogenesis and treatment of diarrhoea.

Authors:  N W Read
Journal:  Scand J Gastroenterol Suppl       Date:  1983

5.  Muscle or mucosa: the site of action of antidiarrheal opiates?

Authors:  D W Powell
Journal:  Gastroenterology       Date:  1981-02       Impact factor: 22.682

6.  Influence of opiates on ion transport across rabbit ileal mucosa.

Authors:  J S McKay; B D Linaker; L A Turnberg
Journal:  Gastroenterology       Date:  1981-02       Impact factor: 22.682

7.  Morphine tissue levels and reduction of gastrointestinal transit in rats. Correlation supports primary action site in the gut.

Authors:  G Bianchi; P Ferretti; M Recchia; M Rocchetti; A Tavani; L Manara
Journal:  Gastroenterology       Date:  1983-10       Impact factor: 22.682

8.  Drug abuse and dependency in patients with chronic pain.

Authors:  T Maruta; D W Swanson; R E Finlayson
Journal:  Mayo Clin Proc       Date:  1979-04       Impact factor: 7.616

9.  Role of alpha-2 adrenergic receptors in the control of diarrhea and intestinal motility.

Authors:  N S Doherty; A A Hancock
Journal:  J Pharmacol Exp Ther       Date:  1983-05       Impact factor: 4.030

10.  The use of clonidine for management of opiate abstinence in a chronic pain patient.

Authors:  G L Bakris; P D Cross; J E Hammarsten
Journal:  Mayo Clin Proc       Date:  1982-10       Impact factor: 7.616

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  5 in total

1.  The narcotic bowel syndrome: clinical features, pathophysiology, and management.

Authors:  David M S Grunkemeier; Joseph E Cassara; Christine B Dalton; Douglas A Drossman
Journal:  Clin Gastroenterol Hepatol       Date:  2007-10       Impact factor: 11.382

2.  Opioid bowel dysfunction and narcotic bowel syndrome: a population-based study.

Authors:  Rok Seon Choung; G Richard Locke; Alan R Zinsmeister; Cathy D Schleck; Nicholas J Talley
Journal:  Am J Gastroenterol       Date:  2009-04-14       Impact factor: 10.864

Review 3.  Preclinical experimental models for assessing laxative activities of substances/products under investigation: a scoping review of the literature.

Authors:  Patiwat Kongdang; Dumnoensun Pruksakorn; Nut Koonrungsesomboon
Journal:  Am J Transl Res       Date:  2022-02-15       Impact factor: 4.060

Review 4.  The Useage of Opioids and their Adverse Effects in Gastrointestinal Practice: A Review.

Authors:  MahmoudReza Khansari; MasourReza Sohrabi; Farhad Zamani
Journal:  Middle East J Dig Dis       Date:  2013-01

Review 5.  A review of the clinical manifestations, pathophysiology and management of opioid bowel dysfunction and narcotic bowel syndrome.

Authors:  Zahra Azizi; Sanam Javid Anbardan; Naser Ebrahimi Daryani
Journal:  Middle East J Dig Dis       Date:  2014-01
  5 in total

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