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Literature DB >> 7908850

Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.

G K Aghajanian¹, J H Kogan, B Moghaddam.

Abstract

Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

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Year: 1994 PMID： 7908850 DOI： 10.1016/0006-8993(94)90186-4

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

42 in total

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3. Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats.

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4. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.

Authors: Daria Rylkova; Jeffrey Boissoneault; Shani Isaac; Melissa Prado; Hina P Shah; Adrie W Bruijnzeel
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5. Interactions of nitric oxide with α2 -adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine.

Authors: Gajanan P Shelkar; Sukanya G Gakare; Suwarna Chakraborty; Shashank M Dravid; Rajesh R Ugale
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10. Modulating effect of the nootropic drug, piracetam on stress- and subsequent morphine-induced prolactin secretion in male rats.

Authors: A Matton; S Engelborghs; F Bollengier; E Finné; L Vanhaeist
Journal: Br J Pharmacol Date: 1996-02 Impact factor: 8.739

Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.

1. Modulation of NMDA receptor subunit mRNA in butorphanol-tolerant and -withdrawing rats.

2. The enigma of morphine tolerance: recent insights.

3. Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats.

4. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.

5. Interactions of nitric oxide with α2 -adrenoceptors within the locus coeruleus underlie the facilitation of inhibitory avoidance memory by agmatine.

6. Correlation between brain nitric oxide synthase activity and opiate withdrawal.

7. Increased opioid dependence in a mouse model of panic disorder.

Review 8. Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

9. Glutamate receptor subunit expression in the rhesus macaque locus coeruleus.

10. Modulating effect of the nootropic drug, piracetam on stress- and subsequent morphine-induced prolactin secretion in male rats.