Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.

Literature DB >> 7907994

beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.

Abstract

Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid beta-amyloid peptide (beta 1-40) interacts with the cyclic oligosaccharide beta-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of beta 1-40 in a cell line.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1994 PMID： 7907994 DOI： 10.1016/0014-5793(94)80467-2

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

Keyword Cloud
Cited

16 in total

1. Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.

Authors: D R Howlett; A E Perry; F Godfrey; J E Swatton; K H Jennings; C Spitzfaden; H Wadsworth; S J Wood; R E Markwell
Journal: Biochem J Date: 1999-05-15 Impact factor: 3.857

2. Investigation of the noncovalent interactions between anti-amyloid agents and amyloid beta peptides by ESI-MS.

Authors: Eric Martineau; Janna M de Guzman; Lioudmila Rodionova; Xianqi Kong; Paul M Mayer; Ahmed M Aman
Journal: J Am Soc Mass Spectrom Date: 2010-05-31 Impact factor: 3.109

3. 2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.

Authors: Xiaopeng Liu; Dalian Ding; Guang-Di Chen; Li Li; Haiyan Jiang; Richard Salvi
Journal: Neurotox Res Date: 2020-06-30 Impact factor: 3.911

4. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.

Authors: Dun-Sheng Yang; Philip Stavrides; Asok Kumar; Ying Jiang; Panaiyur S Mohan; Masuo Ohno; Kostantin Dobrenis; Cristin D Davidson; Mitsuo Saito; Monika Pawlik; Chunfeng Huo; Steven U Walkley; Ralph A Nixon
Journal: Hum Mol Genet Date: 2017-03-01 Impact factor: 6.150

10. Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers.

Authors: Jiaxin Yu; Lara Bakhos; Lei Chang; Mark J Holterman; William L Klein; Duane L Venton
Journal: J Mol Neurosci Date: 2002 Aug-Oct Impact factor: 3.444

beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.

1. Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.

2. Investigation of the noncovalent interactions between anti-amyloid agents and amyloid beta peptides by ESI-MS.

3. 2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.

4. Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.

5. Energetics of cyclodextrin-induced dissociation of insulin.

Review 6. Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease.

Review 7. Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.

8. Mechanism of accelerated assembly of beta-amyloid filaments into fibrils by KLVFFK(6).

9. Cyclodextrins inhibit replication of scrapie prion protein in cell culture.

10. Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers.