OBJECTIVE: To determine serum levels of proteinase 3 (PR3) in normal subjects and patients with Wegener's granulomatosis (WG), polyarteritis nodosa (PAN), chronic renal failure, and systemic lupus erythematosus (SLE). METHODS: Serum levels of PR3 were measured by enzyme-linked immunosorbent assay employing a monospecific rabbit polyclonal antibody against PR3. RESULTS: Quantifiable levels of PR3 were detected in all serum samples examined, including those of normal subjects. Marked elevations of serum PR3, which decreased with treatment, were found in patients with active WG. Patients with PAN, SLE, and chronic renal failure also showed elevated levels of PR3. CONCLUSION: Quantitating serum PR3 may be useful in the management of patients with WG and other connective tissue diseases.
OBJECTIVE: To determine serum levels of proteinase 3 (PR3) in normal subjects and patients with Wegener's granulomatosis (WG), polyarteritis nodosa (PAN), chronic renal failure, and systemic lupus erythematosus (SLE). METHODS: Serum levels of PR3 were measured by enzyme-linked immunosorbent assay employing a monospecific rabbit polyclonal antibody against PR3. RESULTS: Quantifiable levels of PR3 were detected in all serum samples examined, including those of normal subjects. Marked elevations of serum PR3, which decreased with treatment, were found in patients with active WG. Patients with PAN, SLE, and chronic renal failure also showed elevated levels of PR3. CONCLUSION: Quantitating serum PR3 may be useful in the management of patients with WG and other connective tissue diseases.
Authors: Gheath Alatrash; Yoko Ono; Anna Sergeeva; Pariya Sukhumalchandra; Mao Zhang; Lisa S St John; Tian-Hui Yang; Kathryn Ruisaard; Paul M Armistead; Elizabeth A Mittendorf; Hong He; Na Qiao; Tania Rodriguez-Cruz; Shoudan Liang; Karen Clise-Dwyer; Eric D Wieder; Gregory Lizee; Sijie Lu; Jeffrey J Molldrem Journal: J Immunother Date: 2012-05 Impact factor: 4.456
Authors: R Finnern; J M Bye; K M Dolman; M H Zhao; A Short; J D Marks; M C Lockwood; W H Ouwehand Journal: Clin Exp Immunol Date: 1995-12 Impact factor: 4.330
Authors: Mohamed Abdgawad; Åsa Pettersson; Lena Gunnarsson; Anders A Bengtsson; Pierre Geborek; Lars Nilsson; Mårten Segelmark; Thomas Hellmark Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240
Authors: Samantha P Tull; Anne Bevins; Sahithi Jyothsna Kuravi; Simon C Satchell; Bahjat Al-Ani; Stephen P Young; Lorraine Harper; Julie M Williams; George Ed Rainger; Caroline O S Savage Journal: PLoS One Date: 2012-08-29 Impact factor: 3.240