| Literature DB >> 7907235 |
W T Briscoe1, D B Ray, J L Airhart, A L Ratliff, E A Shockley, L Whetsell, F V Schaefer, R M Williams.
Abstract
The HER-2/neu (erbB-2) oncogene, if amplified and/or overexpressed in breast and ovarian cancers, is associated with a poor prognosis. Employing direct DNA sequencing, we have discovered and sequenced an 80 base pair intron from human placenta which contains an A to G polymorphism. This polymorphism lends itself to restriction fragment length polymorphism analysis of the PCR product spanning this intron. All three genotypes, homozygous A, heterozygous, and homozygous G appear in normal control populations and breast tumors. Also, no difference was seen between the polymorphic form found in five breast cancers and the corresponding normal tissue.Entities:
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Year: 1993 PMID： 7907235 DOI： 10.1007/bf00666355
Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.872