Literature DB >> 7907218

Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.

C Harasko-van der Meer1, T Brücke, S Wenger, P Fischer, L Deecke, I Podreka.   

Abstract

Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT. Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%. More attention should be focused on long term effects of neuroleptics.

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Year:  1993        PMID： 7907218     DOI： 10.1007/bf01277026

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  8 in total

1.  Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol.

Authors:  A L Nordström; L Farde; C Halldin
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  In vivo assay for neuroleptic receptor binding in the striatum. Positron tomography in humans.

Authors:  H Cambon; J C Baron; J P Boulenger; C Loc'h; E Zarifian; B Maziere
Journal:  Br J Psychiatry       Date:  1987-12       Impact factor: 9.319

3.  Dopamine receptor occupancy and plasma haloperidol levels.

Authors:  A Wolkin; J D Brodie; F Barouche; J Rotrosen; A P Wolf; M Smith; J Fowler; T B Cooper
Journal:  Arch Gen Psychiatry       Date:  1989-05

4.  Striatal dopamine receptor occupancy during and following withdrawal from neuroleptic treatment: correlative evaluation by positron emission tomography and plasma prolactin levels.

Authors:  J C Baron; J L Martinot; H Cambon; J P Boulenger; M F Poirier; V Caillard; J Blin; J D Huret; C Loc'h; B Maziere
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

5.  Dopamine D2 receptor imaging with SPECT: studies in different neuropsychiatric disorders.

Authors:  T Brücke; I Podreka; P Angelberger; S Wenger; A Topitz; B Küfferle; C Müller; L Deecke
Journal:  J Cereb Blood Flow Metab       Date:  1991-03       Impact factor: 6.200

6.  Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects.

Authors:  L Farde; A L Nordström; F A Wiesel; S Pauli; C Halldin; G Sedvall
Journal:  Arch Gen Psychiatry       Date:  1992-07

7.  GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography.

Authors:  S L Dewey; G S Smith; J Logan; J D Brodie; D W Yu; R A Ferrieri; P T King; R R MacGregor; T P Martin; A P Wolf
Journal:  J Neurosci       Date:  1992-10       Impact factor: 6.167

8.  Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs.

Authors:  L Farde; F A Wiesel; C Halldin; G Sedvall
Journal:  Arch Gen Psychiatry       Date:  1988-01
  8 in total
  1 in total

1.  Ready biodegradability of trifluoromethylated phenothiazine drugs, structural elucidation of their aquatic transformation products, and identification of environmental risks studied by LC-MS( n ) and QSAR.

Authors:  Christoph Trautwein; Klaus Kümmerer
Journal:  Environ Sci Pollut Res Int       Date:  2012-06-08       Impact factor: 4.223
  1 in total

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