| Literature DB >> 7906704 |
M Nishimura1, J Toki, K Sugiura, F Hashimoto, T Tomita, H Fujishima, Y Hiramatsu, N Nishioka, N Nagata, Y Takahashi.
Abstract
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.Entities:
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Year: 1994 PMID： 7906704 PMCID： PMC2191400 DOI： 10.1084/jem.179.3.1053
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307