Literature DB >> 7906414

Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion.

J R Wyatt1, T A Vickers, J L Roberson, R W Buckheit, T Klimkait, E DeBaets, P W Davis, B Rayner, J L Imbach, D J Ecker.   

Abstract

The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The tetramer binds to the human immunodeficiency virus envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.

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Year:  1994        PMID： 7906414      PMCID： PMC43157          DOI： 10.1073/pnas.91.4.1356

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

1.  Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures.

Authors:  C Cheong; P B Moore
Journal:  Biochemistry       Date:  1992-09-15       Impact factor: 3.162

2.  CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.

Authors:  G E FOLEY; H LAZARUS; S FARBER; B G UZMAN; B A BOONE; R E MCCARTHY
Journal:  Cancer       Date:  1965-04       Impact factor: 6.860

3.  A priori delineation of a peptide which mimics a discontinuous antigenic determinant.

Authors:  H M Geysen; S J Rodda; T J Mason
Journal:  Mol Immunol       Date:  1986-07       Impact factor: 4.407

4.  Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.

Authors:  M Fried; D M Crothers
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

5.  Rational screening of oligonucleotide combinatorial libraries for drug discovery.

Authors:  D J Ecker; T A Vickers; R Hanecak; V Driver; K Anderson
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971

6.  Phosphorothioate oligodeoxynucleotides bind to the third variable loop domain (v3) of human immunodeficiency virus type 1 gp120.

Authors:  C A Stein; A M Cleary; L Yakubov; S Lederman
Journal:  Antisense Res Dev       Date:  1993

7.  Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with anti glycosidic torsion angles in solution.

Authors:  Y Wang; D J Patel
Journal:  Biochemistry       Date:  1992-09-08       Impact factor: 3.162

8.  RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase.

Authors:  C Tuerk; S MacDougal; L Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

9.  NMR study of parallel-stranded tetraplex formation by the hexadeoxynucleotide d(TG4T).

Authors:  F Aboul-ela; A I Murchie; D M Lilley
Journal:  Nature       Date:  1992-11-19       Impact factor: 49.962

10.  HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope.

Authors:  S D Putney; T J Matthews; W G Robey; D L Lynn; M Robert-Guroff; W T Mueller; A J Langlois; J Ghrayeb; S R Petteway; K J Weinhold
Journal:  Science       Date:  1986-12-12       Impact factor: 47.728
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  65 in total

1.  The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4)).

Authors:  P Schultze; N V Hud; F W Smith; J Feigon
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

2.  Effects of site-specific guanine C8-modifications on an intramolecular DNA G-quadruplex.

Authors:  Christopher Jacques Lech; Joefina Kim Cheow Lim; Jocelyn Mei Wen Lim; Samir Amrane; Brahim Heddi; Anh Tuân Phan
Journal:  Biophys J       Date:  2011-10-19       Impact factor: 4.033

3.  Resistance to a drug blocking human immunodeficiency virus type 1 entry (RPR103611) is conferred by mutations in gp41.

Authors:  B Labrosse; O Pleskoff; N Sol; C Jones; Y Hénin; M Alizon
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

4.  In vitro selection of RNAs that bind to the human immunodeficiency virus type-1 gag polyprotein.

Authors:  M A Lochrie; S Waugh; D G Pratt; J Clever; T G Parslow; B Polisky
Journal:  Nucleic Acids Res       Date:  1997-07-15       Impact factor: 16.971

Review 5.  Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer.

Authors:  Paula J Bates; Damian A Laber; Donald M Miller; Shelia D Thomas; John O Trent
Journal:  Exp Mol Pathol       Date:  2009-01-20       Impact factor: 3.362

6.  DNA duplexes with hydrophobic modifications inhibit fusion between HIV-1 and cell membranes.

Authors:  Liang Xu; Lifeng Cai; Xueliang Chen; Xifeng Jiang; Huihui Chong; Baohua Zheng; Kun Wang; Junlin He; Wei Chen; Tao Zhang; Maosheng Cheng; Yuxian He; Keliang Liu
Journal:  Antimicrob Agents Chemother       Date:  2013-07-29       Impact factor: 5.191

7.  The 3D structures of G-quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase.

Authors:  Ming-Hui Li; Yi-Han Zhou; Quan Luo; Ze-Sheng Li
Journal:  J Mol Model       Date:  2009-10-04       Impact factor: 1.810

8.  Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties.

Authors:  R G Schultz; S M Gryaznov
Journal:  Nucleic Acids Res       Date:  1996-08-01       Impact factor: 16.971

9.  Possible role of the V3 domain of gp120 in resistance to an amphotericin B derivative (MS8209) blocking human immunodeficiency virus entry.

Authors:  O Pleskoff; N Sol; H Marrakchi; M Serlin; M Seman; M Alizon
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

10.  Anomeric DNA quadruplexes.

Authors:  Natalia A Kolganova; Anna M Varizhuk; Roman A Novikov; Vladimir L Florentiev; Galina E Pozmogova; Olga F Borisova; Anna K Shchyolkina; Igor P Smirnov; Dmitry N Kaluzhny; Edward N Timofeev
Journal:  Artif DNA PNA XNA       Date:  2014
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