| Literature DB >> 7905554 |
R B Markham1, J Coberly, A J Ruff, D Hoover, J Gomez, E Holt, J Desormeaux, R Boulos, T C Quinn, N A Halsey.
Abstract
Maternal-infant transmission of HIV-1 occurs in 13-40% of pregnancies. Studies on transmission of maternal immunity to HIV antigens have used antigens from viruses not representative of clinical isolates and have been conflicting. Using a consensus peptide sequence based on HIV isolates found in Haiti, we found that Haitian mothers who transmitted infection to their offspring had significantly higher mean concentrations of IgG1 antibodies to the V3 loop of the primary neutralising domain of the viral envelope (gp 160) than non-transmitters (p = 0.02). Concentrations of IgA antibody to this domain were similar in transmitters and non-transmitters.Entities:
Keywords: Americas; Antibodies--analysis; Biology; Caribbean; Developing Countries; Diseases; Embryo; Examinations And Diagnoses; Family And Household; Family Characteristics; Family Relationships; Fetus; Haiti; Hiv Infections--transmission; Immunity; Immunologic Factors; Laboratory Examinations And Diagnoses; Laboratory Procedures; Latin America; Mothers; North America; Parents; Physiology; Pregnancy; Reproduction; Viral Diseases
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Year: 1994 PMID： 7905554 DOI： 10.1016/s0140-6736(94)91225-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321